Polygonum aviculare / Varkensgras

De naam varkensgras is waarschijnlijk ontstaan, omdat het als varkensvoer werd gebruikt. Al kan ik mij dat moeilijk voorstellen, want aan dit schrale kruid valt weinig te eten. Zou het mogelijk als vies gras bedoeld geweest zijn? Of zou het medicinaal nuttig zijn voor varkens? Of wil men op deze manier, het ordinaire, het vuile van deze plant uitdrukken, door het ‘varken’ te noemen? Veel vraagtekens, dus ik weet het niet, al opteer ik voor de laatste mogelijkheid. Alhoewel, in de 16de eeuw zou het gebruikt geweest zijn om de eetlust bij varkens te verhogen. Misschien toch iets voor de varkensbio-industrie.

Doordat het zo sterk groeit heeft het ook veel volksnamen gekregen in de trant van ‘kruip bij de weg’, wegengras,en kreupelgras. In sommige streken werd het ook ijzerkruid genoemd. Mogelijk omdat het zo sterk is als ijzer. Als ik het op de zandpaden in de tuin wil weghakken, geraakt de hak er zelfs niet van de eerste keer doorheen. http://mens-en-gezondheid.infonu.nl/aandoeningen/40083-varkensgras-verleden-en-heden.html


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Biol Res. 2006;39(2):281-8. Epub 2006 Jul 25. Antioxidant activity of extract from Polygonum aviculare L. Hsu CY.

Free radicals induce numerous diseases by lipid peroxidation, protein peroxidation, and DNA damage. It has been reported that numerous plant extracts have antioxidant activities to scavenge free radicals. Whether Polygonum aviculare L. (Polygonaceae) has antioxidant activity is unknown. In this study, dried Polygonum aviculare L. was extracted by ethanol, and the extract was lyophilized. The antioxidant activities of extract powder were examined by free radical scavenging assays, superoxide radical scavenging assays, lipid peroxidation assays and hydroxyl radical-induced DNA strand scission assays. The results show that the IC50 value of Polygonum aviculare L. extract is 50 microg/ml in free radical scavenging assays, 0.8 microg/ml in superoxide radical scavenging assays, and 15 microg/ml in lipid peroxidation assays, respectively. Furthermore, Polygonum aviculare L. extract has DNA protective effect in hydroxyl radical-induced DNA strand scission assays. The total phenolics and flavonoid content of extract is 677.4 +/- 62.7 microg/g and 112.7 +/- 13 microg/g. The results indicate that Polygonum aviculare L. extract clearly has antioxidant effects.

Phytomedicine 2018 Mar 15;42:180-189. doi: 10.1016/j.phymed.2018.03.042. Epub 2018 Mar 19.

Polygonum aviculare L. extract reduces fatigue by inhibiting neuroinflammation in restraint-stressed mice

Sun Haeng Park 1, Seol Jang 2, Eunjung Son 2, Si Woo Lee 3, Sun Dong Park 4, Yoon-Young Sung 2, Ho Kyoung Kim 5


Background: Chronic fatigue patients experience various neuropsychological symptoms, including fatigue behaviors, chronic pain, and depression. They also display immune system dysregulation. Polygonum aviculare L. extract (PAE) is a traditional herbal medicine used to treat inflammatory diseases by reportedly decreasing pro-inflammatory cytokine production.

Hypothesis/purpose: We hypothesized that the anti-inflammatory properties of PAE would attenuate fatigue symptoms in a mouse model of restraint stress.

Study design: We evaluated the effects of PAE on fatigue using three experimental groups: unstressed, vehicle-treated stressed, and PAE-treated stressed mice. This restraint stress paradigm, comprised of restraint for 3 h daily for 15 days, was used to model chronic fatigue.

Methods: We compared lethargy-like behavior between our experimental groups using forced-swim, sucrose preference, and open-field tests once per week on days 7 and 14 of restraint stress. We also used histology and western blotting to evaluate pro-inflammatory cytokine expression in the brain and serum, and microglial activation in the brain. Finally, we used liquid chromatography/mass spectroscopy (LC/MS) to identify individual components of PAE, and applied cell culture techniques to test the effects of these components on neuronal cells in vitro.

Results: In restraint-stressed mice, PAE treatment decreased lethargy-like behavior relative to vehicle-treated animals. PAE treatment also reduced expression of fatigue-related factors such as corticosterone, serotonin, and catecholamines (adrenaline and noradrenaline) in the brain and serum, and decreased expression of CD68, Ibal-1, and the inflammatory cytokines TNF-α, IL-6, and IL-1β in the brain. Together, these data indicate that PAE reduced fatigue and is anti-inflammatory. Furthermore, histopathological analyses indicated that PAE treatment recovered atrophic volumes and hepatic injuries. Finally, LC/MS analysis of PAE identified four individual chemicals: myricitrin, isoquercitrin, avicularin, and quercitrin. In neuronal cell cultures, treatment with these PAE components inhibited TNF-α production, confirming that PAE treatment reduces neuroinflammation.

Conclusions: PAE treatment may reduce fatigue by suppressing neuroinflammation and the expression of fatigue-related hormones.

Phytother Res. 2016 May;30(5):848-54. doi: 10.1002/ptr.5593. Epub 2016 Mar 1.

Polygonum aviculare L. and its active compounds, quercitrin hydrate, caffeic acid, and rutin, activate the Wnt/β-catenin pathway and induce cutaneous wound healing

Seol Hwa Seo 1 2, Soung-Hoon Lee 1 2, Pu-Hyeon Cha 1 2, Mi-Yeon Kim 1 2, Do Sik Min 3, Kang-Yell Choi 1 2

Polygonum aviculare L. is a member of the Polygonaceae family of plants, which has been known for its antioxidant and anti-obesity effects. However, the wound healing function of P. aviculare extract has not been assessed. In this study, we identified a novel property of P. aviculare extract as a Wnt/β-catenin pathway activator based on a screen of 350 plant extracts using HEK293-TOP cells retaining the Wnt/β-catenin signaling reporter gene. P. aviculare extract accelerated the migration of HaCaT keratinocytes without showing significant cytotoxicity. Moreover, P. aviculare extract efficiently re-epithelized wounds generated on mice. Additionally, ingredients of P. aviculare extract, such as quercitrin hydrate, caffeic acid, and rutin, also accelerated the motility of HaCaT keratinocytes with the activation of Wnt/β-catenin signaling. Therefore, based on our findings, P. aviculare extract and its active ingredients could be potential therapeutic agents for wound healing. Copyright © 2016 John Wiley & Sons, Ltd.

Urol J. 2018 May 3;15(3):79-82. doi: 10.22037/uj.v0i0.3815.

Effect of Polygonum Aviculare L. on Nephrolithiasis Induced by Ethylene Glycol and Ammonium Chloride in Rats

Jamileh Saremi 1, Hossein Kargar Jahromi 2, Mohammad Pourahmadi 1

Purpose: Nephrolithiasis is a common urinary tract disease, in addition to the pain and treatment costs, there may be significant complications resulting from the stones. This study intended to investigate the effects of Polygonum Aviculare L. aqueous extract (PAE) on urolithiasis induced by ethylene glycol (EG) and ammonium chloride (AC) in rats.

Materials and methods: Sixty-four male Wistar rats were randomly divided into eight groups (n = 8). Rats in the normal control group (I) received no treatment. The sham groups (III and IV) were given PAE. at 100 and400 mg/kg by gavage for 28 days. The disease control group (II), the prevention groups ( V and VI), and the therapeutic groups (VII and VIII), received 1% EG and .25 AC in their drinking water for 28 days. The prevention groups (from the start of EG administration), and the therapeutic groups (from the 14th day of EG administration),received PAE at 100 and 400 mg/kg by gavage. At the end of the experiment, kidneys were examined for CaOx deposits and tubulointerstitial changes.

Results: The number of CaOx crystals and tubulointerstitial changes increased significantly in group II rats compared to groups I, III, and IV (P < .001). The number of CaOx crystals (P < .001) and tubulointerstitial changes (P < .001) in the prevention groups, and the number of CaOx crystals (P < .05) and interstitial changes (P < .05) inthe therapeutic groups declined significantly compared to group II.

Conclusion: Results show aqueous extract of Polygonum Aviculare L. is effective in the prevention and treatment of kidney stones.

Daru. 2011;19(5):326-31.

Effects of polygonum aviculare herbal extract on proliferation and apoptotic gene expression of MCF-7

Roudkenar M Habibi 1, Roushandeh A Mohammadi, A Delazar, R Halabian, Rad J Soleimani, A Mehdipour, M Bagheri, A Jahanian-Najafabadi

Background and the purpose of the study: One of the most common malignancies in women is breast cancer. Although several treatments for breast cancer are available, application of herbal medicine as a supplementary treatment is a new option to help curing the disease. In this study anticancer effects of Polygonum avicular herbal extract was investigated.

Methods: Polygonum avicular extract was obtained by methanol. MCF-7 cell line was treated with different concentrations of Polygonum avicular (50, 100, 150, 200, 250, 300,350 400 ng/µl) for different time lengths ( 6, 12, 24, and 48 hrs). MTT assay and Flow Cytometry were used to evaluate cell proliferation and apoptosis, respectively. RT-PCR was also carried out to evaluate the expression of apoptotic genes.

Results and discussion: Results showed that Polygonum avicular induced cytotoxicity in MCF-7 cell line at concentrations higher than 300 ng/µl and this was confirmed by the highest rate of cell death as measured by Trypan Blue and MTT assays. RT-PCR results showed up-regulation of P53 and down-regulation of Bcl-2 proteins which implied the ability of Polygonum avicular to induce apoptosis in MCF-7 cells and confirmed its anticancer property. Further studies are required to evaluate effects of the extract on other apoptotic genes.

Andere soort Polygonum maritimum