MacGyver (1985-1992)
Richard Dean Anderson stars as secret agent Angus MacGuyver - a man whose quick-thinking resourcefulness can get him out of any scrape. This show took place all over the world, but mainly took advantage of locations around Los Angeles. In its third season, it moved to Vancouver, BC where it remained until the end of its 7-season run.
Kate at Richard Dean Anderson Website has done an exhaustive amount of research into the filming locations seen in the show, and her site has a wealth of photos & maps. Go check it out!