Funding

Canada Research Chair, Tier II

 Imaging Approaches Towards Studying Infection

Canadian Foundation for Innovation, John R. Evans Leaders Fund

Intravital Imaging of Viral and Bacterial Infections: 

Supports the purchase, development and maintenance of advanced imaging infrastructure for the study of highly pathogenic infectious organisms.

Snyder Institute Clinical Incubator Award 

MIBI Study: Non-alcoholic fatty liver disease (NAFLD): 

(Principal Applicant with Dr. Swain, Dr. Kelly, Dr. Nguyen) - This project aims use MIBI to map the inflammatory cell landscape associated with non-alcoholic fatty liver disease (NAFLD).  

Canadian Network for Modelling Infectious Diseases 

A Multiscale Mechanistic Modelling Approach to Virus Propagation in a Heterogeneous Population: 

(Co-PI with Dr. Williamson, Dr. Wan) - This project aims to use the principles of  granular mechanics with existing social, epidemiological, and economic models to produce a robust and flexible model of virus transmission

Canadian Institutes of Health Research Project Grant 

Evaluating Cancer-associated Thrombosis Mechanisms to Inform Personalized Thromboprophylaxis in Patients with Metastatic Bone Disease: 

(Co-Applicant with Dr. Schneider, Dr. McDonald + 7 others ) - This project aims to understand the elevated clotting risk in metastatic bone cancer patients.  

Canadian Institutes of Health Research Project Grant 

Mapping the Role of Platelets in Influenza-Associated Thrombosis in Peripheral Vasculature by Intravital and Super-Resolution Imaging: 

(Principal Applicant with Dr. Deniset, Dr. Dufour, Dr. Heit) - This project will utilize a mix of imaging approaches and animal models to study the link between influenza infection and peripheral vascular pathology. 

Canadian Institutes of Health Research Project Grant 

Investigation of Hepatitis B Virus Immunopathogenesis using Intravital Microscopy in the Woodchuck Hepatitis Virus (WHV) Model of Hepatitis B: 

(Principal Applicant with Dr. Coffin, Dr. Michalak) - This project will utilize intravital microscopy to study infection and inflammation in the liver of a woodchuck hepatitis virus-mediated  model of disease. 

Canadian Institutes of Health Research Project Grant 

Brain-Derived Neurotrophic Factor in hemostasis and thrombosis: 

(Co-Applicant with Dr. Lordkipanidzé, Dr. El Jerdi) - This project seeks to uderstand the role of BDNF in clot formation and interaction with  the immune system.. 

Canadian Institutes of Health Research Project Grant 

Mechanisms Underlying Oncolytic Rhabdovirus-mediated Anti-cancer Immunity: 

(Co-applicant with Dr. Doug Mahoney) – Research funding to support the development and delivery of oncolytic viruses as an immunotherapy for the treatment of cancer.

Natural Science and Engineering Research Council of Canada (NSERC) Discover Horizons Grant

 A mechanistic computational framework for modelling a pandemic and socio-economic response against new virus variants: 

(Co-applicant with Dr. Wan, Dr. Williamson, Dr. Black) Research funding to apply the principles of  granular mechanics with existing social, epidemiological, and economic models to produce a robust and flexible model of virus transmission

Beverley Phillips Rising Star Postdoctoral Fellowship

Using intravital microscopy to track viral delivery, infection and clearance in a mouse model of gene therapy: 

This fellowship helped facilitate the recruitment of Agostina Carestia from Argentina to join our research team in Calgary 

The University of Calgary, Cumming School of Medicine Postdoctoral Scholar Program 

Using intravital microscopy to track viral delivery, infection and clearance in a mouse model of gene therapy: 

This fellowship helped facilitate the recruitment of Agostina Carestia from Argentina to join our research team in Calgary 

  University of Calgary Eyes High Doctoral Scholarship 

The role of viral infection in leukocyte recruitment during oncolytic virus therapy: 

This studentship allowed the recruitment of Madison Turk from the University of Western Ontario to join our research team in Calgary.

The NSERC Alexander Graham Bell Scholarship

This Scholarship was award to Madison Turk to support her studies focused on the use of oncolytic viruses as an immunotherapy to treat cancer.

Metis Education Foundation Scholar Award 

Investigating the immune response to viral infection in the context of non-alcoholic fatty liver disease: 

This studentship was awarded to Rachelle Davis

Alberta Graduate Excellence Scholarship (AGES) - Doctoral Research Award

 Investigating the immune response to viral infection in the context of non-alcoholic fatty liver disease (NAFLD): 

This studentship was awarded to Rachelle Davis

Canadian Liver Foundation Graduate Studentship 

Assessing the efficacy of hepatitis B vaccination in the context of non-alcoholic fatty liver disease: 

This studentship was awarded to Rachelle Davis

University of Calgary Faculty of Graduate Studies Indigenous Graduate Award

Investigating the immune response to viral infection in the context of non-alcoholic fatty liver disease (NAFLD): 

This studentship was awarded to Rachelle Davis 

University of Calgary Faculty of Graduate Studies Queen Elizabeth II Graduate Scholarship

Mechanisms of Oncolytic Virus-Mediated Vascular Collapse: 

This studentship was awarded to Rachelle Davis. 

Natural Science and Engineering Research Council of Canada (NSERC) Discover Grant

 Development of Imaging Approaches to Study Coagulation In Vivo: 

Research funding to develop a multifunctional imaging platform and novel fluorescent probes to study coagulation in live animals, in real-time

Canadian Cancer Society Research Institute (CCSRI) Innovation Grant 

(Co-PI with Dr. Douglas Mahoney) Understanding oncolytic virus delivery using intravital imaging: 

Research funding to study how oncolytic viruses “find” and infect tumours and how these viruses may interact with leukocytes within the bloodstream and the tumour. 

Critical Care Strategic Clinical Network

The Role of Platelets and Neutrophil Extracellular Traps (NETS) in Disseminated Intravascular Coagulation (DIC): 

Research support to study how immune effector molecules (NETS) directly interact with and platelets leading to infection-induced coagulopathy. 

CIHR Operating Grant: 

Innovative Ebola Research Grants – Ebola Biology –  Deciphering the signaling mechanisms underlying Ebola virus-mediated inflammatory response upon interaction/entry with human macrophages (collaborator, grant PI is Dr. Marceline Cote): 

Research support to study in vivo how viral particles are captured and processed as a basis for the development of viral vaccine vectors. 

CIHR Industry-Partnered Collaborative Research Grant: 

Pathogenesis of Hepatitis B Virus Infection in Non-Alcoholic Fatty Liver Disease 

(Co-Applicant with Dr. Carla Coffin and Dr. Saumya Jayakumar; Partnered with GlaxoSmithKline): Research funding to study Hep B pathogenesis, immune function and vaccination efficiency in patients with non-alcoholic fatty liver disease. 

Critical Care Strategic Clinical Network

 Identification of a bioprofile in children with appendicitis who have severe disease requiring PICU (collaborator, grant PI is Dr. Jamie Blackwood): 

Research support for a clinical study looking to identify a protein/metabolite “fingerprint” that will help identify children with severe appendicitis

The Lung Association of Alberta & NWT National Grant 

Review - Role of intravascular thrombin on platelet activation and lung inflammation during Influenza A virus infection: 

Research funding to understand the role of thrombin generation and platelet activation during a mouse model of highly pathogenic flu infection. 

The Lung Association of Alberta & NWT National Grant 

Review -  Role of tissue factor in the initiation of inflammation in response to Influenza A virus infection: 

Research funding to understand the role of tissue factor in a mouse model of highly pathogenic H1N1 influenza infection.

University Research Grants Committee (URGC) Faculty Seed Grant

Mapping the host inflammatory response to highly pathogenic influenza A infection: 

Research funding to develop a lung model of highly pathogenic H1N1 infection for intravital imaging in mice.

Cumming School of Medicine Office of the Associate Dean Research (OADR) Bridge Funding

Interaction between inflammation, immunity and coagulation in highly pathogenic influenza infection: 

Research funding to develop a lung model of highly pathogenic H1N1 infection for intravital imaging in mice. 

New Frontiers in Research Fund (NFRF)

Advanced Microscopic Imaging of Living Human Liver: 

(Co-applicants Dr. Carla Coffin [UofC]; Dr. Doug Mahoney [UofC]; Dr. Zania Stamataki [University of Birmingham]) - Support to build live human tissue perfusion and imaging infrastructure.

Heart and Stroke Foundation of Canada (HSFC) Grant-In-Aid

The Role of Platelet Activation in Pathogen-induced Coagulopathy: 

Research funding to study the impact of intravascular infection and the resulting immune response on platelet activation, coagulation, blood flow and tissue health 

Women in Insurance Cancer Crusade - Intravital Microscopy and Cancer

 Research funding to support studies using intravital microscopy to study oncolytic virus-based immunotherapies for the treatment of cancer.

Canadian Institutes of Health Research Canadian 2019 Novel Coronavirus (2019-nCoV) Rapid Research Grant  

Socio-Cultural Implications of COVID-19: Educating, Engaging & Empowering the Public: 

(Collaborator with Dr. Parsons Leigh, Dr. Fiest, Dr. Fowler, Ms. Foster, Ms, Kupsch, Ms Longmore, Dr. Stelfox, Dr. Straus) - This project will help develop strategies to combat misinformation, stigma, and fear related to COVID-19.

 Canadian Institutes of Health Research Canadian 2019 Novel Coronavirus (2019-nCoV) Rapid Research Grant

Therapeutic approaches to SARS-CoV-2 and other pathogenic coronaviruses: 

(Co-Applicant with Dr. Hobman, Dr. Evans, Dr. Julien, Dr. Victoria Ansalem, Dr. Czub, Dr. van Marle, Dr. Nagata) - This project will help explore novel antiviral therapies and novel vaccine approaches to treat and prevent COVID-19 resulting from infection with SARS-CoV-2.

Canadian Institutes of Health Research Canadian 2019 Novel Coronavirus (2019-nCoV) Rapid Research Grant 

Development of Vaccines to Prevent SARS-CoV-2 Infection of High-Risk Individuals: 

(Co-Applicant with Dr. Bell, Dr. Ilkow, Dr. Lapointe, Dr.  Mahoney, Dr. Angel, Dr. Auer, Dr. Bohm, Dr. Cailhier, Dr. Cameron, Dr. Diallo, Dr. Jamison, Dr. Russell-Ladrigue) - This project will develop a virus-delivered COVID-19 vaccine platform. Studies will take advantage of the new BSL3 facility in Calgary to directly assess the efficacy of these novel vaccine strategies.

Canadian Institutes of Health Research Canadian 2019 Novel Coronavirus (2019-nCoV) Rapid Research Grant 

Imaging COVID-19 Lungs to Uncover Therapies: 

(Co-Applicant with Dr. Kubes, Dr. Corcoran, Dr. Gillrie, Dr.  Mody, Dr. Kelly, Dr. McDonald, Dr. Peters) - This project will utilize a mix of experimental approaches within the BSL3 facility at the University of Calgary to map mechanisms of the host immune response and viral pathology. 

CIHR Institute of Circulatory and Respiratory Health Priority Announcement 

Mapping the Role of Platelets in Influenza-Associated Thrombosis in Peripheral Vasculature by Intravital and Super-Resolution Imaging: 

(Principal Applicant with Dr. Deniset, Dr. Heit) - This project will utilize a mix of imaging approaches and animal models to study the link between influenza infection and peripheral vascular pathology. 

CIHR Institute of Infection and Immunity Priority Announcement 

Investigation of Hepatitis B Virus Immunopathogenesis using Intravital Microscopy in the Woodchuck Hepatitis Virus (WHV) Model of Hepatitis B: 

(Principal Applicant with Dr. Coffin, Dr. Michalak) - This project will utilize intravital microscopy to study infection and inflammation in the liver of a woodchuck hepatitis virus-mediated  model of disease. 

CIHR Catalyst Grant: STBBI Research in Canada: Beyond HIV/AIDS 

Development of a Canadian Hepatitis B Virtual Centre of Excellence: 

(Co-Applicant with Dr. Coffin + 8 others ) - This project supports the building a a nationwide virtual network of hepatitis B researchers, care , and patients.  

CIHR Patient-Oriented Research Priority Announcement 

Evaluating Cancer-associated Thrombosis Mechanisms to Inform Personalized Thromboprophylaxis in Patients with Metastatic Bone Disease: 

(Co-Applicant with Dr. Schneider, Dr. McDonald + 7 others ) - This project aims to understand the elevated clotting risk in metastatic bone cancer patients.