Capital Newspaper

Capital Newspaper, Annapolis, MD

You're sitting in the kitchen going through the day's mail. You tear open an unfamiliar envelope and out spills a fine white powder. What do you do? Call the police? Call an ambulance? Run screaming from the house? Maybe call the terrorism hotline that Homeland Security is always flashing on highway traffic signs? Maybe you should just clean up the spilled powder, wash your hands and finish sorting the mail. Statistically, that is the most sensible thing to do.

According to CNN, there were more than 15,000 anthrax hoaxes between September 2001 and August 2002. Previously, the Center for Nonproliferation Studies counted more than 400 anthrax hoaxes between 1998 and September 2001. In late 1998, the Centers for Disease Control and Prevention (CDC) reported seven anthrax threats; another thirty-five threats were made during February 1999. A subsequent article in the Bulletin of the Atomic Scientists (July/ August 1999) suggested anthrax hoaxes were fast replacing telephoned bomb threats as the favorite sport of the disturbed, the disgruntled, and the just plain stupid.

The first widely reported mailing of an anthrax threat occurred in 1997 when the B'nai B'rith office in Washington, D.C. received a package labeled "anthrachs." It was not anthrax. Neither were the thousands of other powders mailed to various people and businesses over the years. Most of the mailed powders turned out to be flour, sugar, sand, baby powder, powdered Tylenol, grated cheese and other innocuous materials. There has been only one event in which someone mailed spores of pathogenic Bacillus anthracis.

In that case, five to seven letters were mailed to a handful of well-known individuals and offices. The opened letters released billions of wispy anthrax spores into enclosed, high-traffic work areas and produced 11 minor cases of cutaneous anthrax, 6 non-fatal cases of inhalational anthrax, and 5 cases of fatal inhalational anthrax among two postal workers and three elderly mail recipients. There have been no further mailings of real anthrax spores.

Each year the U.S. Postal Service delivers about 107 billion pieces of First Class mail to roughly 240 million adults. The odds of receiving a random piece of mail containing a white powder are vanishingly small. The odds of receiving real anthrax are essentially zero. The numbers are on your side. So why worry?

Unless you call 911 about that 'suspicious powder' in your mail. Then you'll have something to worry about. The police will show up with lights flashing. Maybe they'll bring along one of their federally funded robots. Hazmat crews in Tyvek suits will rush into your house. You'll be removed and perhaps made to strip and shower outside as so many others have before. Your house may be quarantined as crews roam around inside sampling the air and the countertops. Maybe your neighbors will be evacuated too.

The local news crews will arrive and film you being taken away for a medical exam. The FBI may show up too. They'll want you to name possible suspects responsible for the 'suspicious powder' in your mail. You may become a suspect yourself because people have been known to make false claims and accusations for 15 minutes of fame. You may become a 'person of interest:' that persistent, mysterious category of person who is neither suspect nor victim but someone to add to the federal watch lists.

Worse still, the police and the FBI, wandering through your house and poking through your possessions, may find things that suggest possible criminal or terrorist activity. That's exactly what happened to an art professor in upstate New York ("Art Becomes the Next Suspect in America's 9/11 Paranoia," The Guardian, June 11, 2004). Now he and a genetics professor in Pittsburgh are facing numerous charges and twenty years in prison ("U.S. Prosecutes Professors for Shipping Microbes," Science, July 9, 2004).

Adding insult to injury, your insurance agent may show up at some point to tell you that your policies don't cover any clean up costs, damages or inconveniences related to infectious diseases. Last November, the American Association of Insurance Services (aais.org) filed a new virus and bacteria exclusion designed to prevent insurance company losses that may arise from claims related to infectious diseases and bioterrorism.

"Coverage is excluded for loss, cost, or expense caused by, resulting from, or relating to any virus, bacterium, or other microorganism that causes or is capable of causing disease, illness, or physical distress. In addition, the exclusion explicitly applies to any loss, cost or expense arising from denial of access to property because of any...microorganisms."

The exclusion is designed for commercial and farm insurance policies, but there is no reason to think it will not eventually trickle down to homeowners and small businesses. Police. Hazmat. News crews. Street-side decontamination. People wandering through your house. Questions from the FBI, and nagging phone calls to your insurance agent. It's a lot of trouble and a huge legal and financial risk because of Sweet'N Low or talcum powder in an envelope. The hoaxers know the havoc they can create with a thirty-nine cent stamp and a cheap envelope. In the end, the best defense may be to defy the hoaxers by showing no reaction to their actions.

Edward McSweegan is a microbiologist and writes a column on infectious diseases for The Capital newspaper in Annapolis, Md.

http://www.opednews.com/articles/opedne_edward_m_061209_hoaxes_2c_statistics_a.htm

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Date: Mon, 02 Jul 2007 21:43:13 +0200

Pathogens & People:

Internet helps spread delusion that Morgellons a disease

By EDWARD McSWEEGAN, For The Capital

I thought the following might be an interesting experiment: Invent a disease and a set of vague symptoms. Build a Web site and start a tax-exempt charity for the disease. Send out press releases about the newly discovered disease and its disturbing symptoms and provide a link to the Web site. Then sit back and see how many people come to the site or call the foundation claiming to have the disease.

Such an experiment probably would reveal quite a bit about the powers of suggestion, hypochondria and the expanding reach of the Internet.

Unfortunately, someone has done my experiment.

A South Carolina housewife came up with a disease she calls Morgellons and a set up a tax-exempt charity called the Morgellons Research Foundation. Apparently, her son had a rash and, instead of going to the doctor, she started snooping around the Internet for a possible cause. She came across some medical references (from the 17th century) that may have described something similar to her son's "condition" and she latched onto the name. She now has about 7,000 fellow Morgellons sufferers. That's an impressive number of hypochondriacs with online access.

In 2006, Hillary Rhodes, a reporter in Ohio did a story on the Morgellons Research Foundation. She wrote, "Don't visit that (Web) site, though. You might get swept up in what some people believe is a case of mass hysteria. If that's what Morgellons is, it would be the first apparent case to spring from the Internet."

So what exactly is Morgellons disease? From the patient perspective, it's a bizarre skin condition in which worm-like fibers of various colors emerge from lesions on the skin.

"I was feeling things moving under my skin," one patient reported.

From the perspective of most physicians, Morgellons is just another form of delusional parasitosis. Delusional parasitosis is a well-known psychiatric condition in which patients believe they are infested by bugs, worms or parasites crawling on them or under their skin.

To be fair, there are a variety of fleas, bedbugs, lice, mites and ticks that bite and feed on skin. They often leave bite marks that swell and itch, and which may become infected if scratched repeatedly.

But in the absence of obvious bite marks from insects and arthropods, or allergic reactions, many physicians are forced to consider a psychiatric origin for the patient's complaints.

"The patient is intensely anxious, is obsessively focused on his or her symptoms, brings "specimens" of the offending agent … and is unshakable in his or her belief as to the cause," University of Pennsylvania professor Caroline Koblenzer wrote last November. "Elderly women living alone are the most common demographic. Psychiatric co-morbidity, such as depression, anxiety or personality disorder, can usually be uncovered during a careful interview."

Interestingly, delusions, such as contagious diseases, can be spread from one susceptible person to another susceptible person. This is how the Internet can serve as a "vector" or transmitter of illness.

Sociologist Robert Batholomew recently suggested the "World Wide Web has become the incubator for mass delusion and it (Morgellons) seems to be a socially transmitted disease over the Internet."

Such beliefs also are reinforced by a handful of doctors who claim Morgellons is real and treat patients with a variety of antibiotics and expensive supplements. (These are the same doctors who treat people for chronic fatigue, chronic Lyme disease, Gulf War Syndrome, Multiple Chemical Sensitivity and other poorly defined syndromes and symptoms.)

Connected and contaminated by the Internet, Morgellons patients have spread the effects of their shared delusions at least as far as Capital Hill, where Sen. Dianne Feinstein, D-Calif., urged the Centers for Disease Control and Prevention to investigate the matter, and to the CDC where self-diagnosed Morgellons patients were telephoning 20 times a day demanding help.

So now the CDC is investigating Morgellons disease. Last summer, a 12-person task force assembled to review patient data, and develop a case definition for Morgellons disease in order to distinguish its symptoms from those of other well-known diseases. It's not clear how much time and money will be spent investigating a disease imagined in a South Carolina suburb and propagated through the Web.

"There really is no scientific basis at this point to believe that this is real. Many patients with symptoms similar to Morgellons respond well to antipsychotics," Stephen Stone, president of the American Academy of Dermatology told Nature Medicine magazine last summer.

"Seinfeld" character George Costanza nicely summed up the problems of dermatology and skin when he declared, "Wash it, dry it, move on!" Today, in the Internet Age, he probably would say, "Wash it, dry it, log off!"

__________________________________________________________________

Dr. Edward McSweegan has a Ph.D. in microbiology and lives in Crofton. He works on and writes about infectious disease issues. He may be contacted at emcsweegan@xxxxxxxx

Published July 01, 2007, The Capital, Annapolis, Md.

http://www.scribd.com/doc/6393353/Big-Bugs-Little-Bugs

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Pathogens and People: A look at the other swine infection

Newspaper article from: Capital (Annapolis) ...killing a small number of people in several countries...another reminder that many pathogens can make the leap from bird and animal to people. Another pathogen that has made the leap...China had 790 million people and 5.2 million pigs...Dr. ...

Pathogens and people: RSV vaccine a challenge for scientists

Newspaper article from: Capital (Annapolis) ...to early July in others. This errant pathogen is called the Respiratory Syncytial Virus...cdc.gov / rsv. --- Dr. Edward McSweegan has a Ph.D. in microbiology and lives...disease issues. He may be contacted at mcsweegan@nasw.org. {Corrections:} {Status...

Pathogens and people: A tick virus with a dangerous bite

Newspaper article from: Capital (Annapolis) ...Most bacterial and parasitic pathogens carried by this tick require...transmission, which sometimes allows people to find and remove the tick...found. --- Dr. Edward McSweegan has a Ph.D. in microbiology...issues. He may be contacted atmcsweegan@nasw.org. ...

Pathogens, as with people, come in all shapes and sizes

Newspaper article from: Capital (Annapolis) ...the sometimes complex interactions of pathogens, environments and hosts. But what...sometimes the victim of yet a smaller pathogen. In August, French scientists reported...that infect viruses has a number of people asking, "How can a virus - something...so, ad infinitum. --- ...

Pathogens and People: Legionella not always dangerous

Newspaper article from: Capital (Annapolis) ...Legionella pneumophila. People usually become infected...Philadelphia. Over 200 people came down with pneumonia...Medical Center's SpecialPathogens Lab in Pittsburgh...pneumophila is a wimpy pathogen. It goes after people who are already ...

Pathogens & People: Bats' reputation: From bad to worse

Newspaper article from: Capital (Annapolis) ...after biting 1,300 people and killing 23 of them...source of rabies and other pathogens, including a fungus...countries where more people are moving into areas...to be made to educate people about handling bats or...viruses. --- Dr. Edward ...

Pathogens & People: TB common and uncommonly difficult to treat

Newspaper article from: Capital (Annapolis) ...tuberculosis suggests this respiratory pathogen may have existed among East African...century, TB killed one out of every seven people in the U.S. and Europe. Yet, as...of unusual, or "opportunistic," pathogens quickly entered the breach. One of...another TB skin test. --- ...

Pathogens & People: Are we too clean for our own health? It's possible

Newspaper article from: Capital (Annapolis) ...America. There is some direct evidence for the ability ofpathogens and parasites from the "dirtier" environments of the...sn_arc99 / 8_14_99 / bob2.htm --- Dr. Edward McSweegan has a Ph.D. in microbiology and lives in

Pathogens & People: Getting the flu vaccine: Erring on the side of caution

Newspaper article from: Capital (Annapolis) ...percent of flu deaths occur among people aged 65 and older. Given the...virus also has killed about 120 people, and has a mortality rate...dangerous research with a dangerous pathogen. Mary Shelley's Dr. Frankenstein...Mother Nature. --- Edward McSweeganhas ...

Pathogens & People

Newspaper article from: Maryland Gazette ...persistent, perplexing pathogen Most baby boomers share...unvaccinated or immunodeficient people. Other cases have appeared...to spread among otherpeople the Sabin poliovirus...dozen children. Should people continue to use and receive...polio. --- Dr. ...

http://www.encyclopedia.com/searchresults.aspx?q=Pathogens+and+People+McSweegan

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Pathogens & People: Pathogens, as with people, come in all shapes and sizes

By EDWARD McSWEEGAN, For The Capital

Published October 05, 2008

So, naturalists observe, a fleaHas smaller fleas that on him prey; And

these have smaller still to bite 'em, And so proceed ad infinitum.

These lines from Jonathan Swift's classic poem, ''a Rhapsody,'' about how the

little are eaten by the big and the big by the bigger is a rule of nature that also

applies in the very small world of microorganisms. You might not think microbes

have a lot of size variation, but they do, and size matters. It determines who

infects whom.

Let's look at the scale of small things. Our red blood cells are about 10

micrometers in diameter. Common E. coli bacteria are two micrometers long.

The smallpox virus measures about 0.2 micrometers, and the bacteriophage virus

that infects E. coli is 0.06 micrometers. As a rule, human cells are bigger than

bacterial cells, which are bigger than viruses. A microscope usually is needed to

see cells and an electron microscope is needed to see the ghostly geometric

shapes of viruses. But there are exceptions.

Epulopsicium fishelsoni is one such exception. At 250 micrometers, this giant,cigar-shaped bacterium can be seen with the naked eye. The smallpox virus isanother microbial giant. Smallpox viruses can be seen in infected cells with a high-quality light microscope.

Smallpox was the big boy in the viral neighborhood until 2003 when the

Mimivirus was discovered. Because of its size (0.4 micrometers) and genetic

complexity (900 genes of double-stranded DNA), Mimivirus initially was

mistaken for a bacterium. As with the bacteria that cause Legionnaire's disease, the Mimivirus was found lurking inside amoeba, which were living in the water of cooling towers. And like the Legionella bacteria, Mimivirus also causes human disease. In 2004, one of the French scientists studying Mimiviruses became infected and developed pneumonia. Recent research has found that about 10 percent of pneumonia patients have antibodies to Mimivirus. The giant Mimivirus uses water-borne amoeba to replicate, and perhaps as a Trojan horse to get into human lungs to cause pneumonia. It is an interesting example of the sometimes complex interactions of pathogens, environments and hosts. But what's really interesting is that Mimivirus is sometimes the victim of yet a smaller pathogens. In August, French scientists reported Mimiviruses can be infected by a tiny virus called a virophage. A Mimivirus infects an amoeba in order to make more copies of itself, but can have its replication hijacked by an infecting virophage, which then makes more copies of itself at the expense of the Mimivirus. (Who knew so much was going on inside an amoeba?) Traditionally, viruses have not been considered "alive" because they lack metabolic functions and they spontaneously assemble like someone's clever piece of nanotechnology. So the discovery of viruses that infect viruses has a number of people asking, "How can a virus - something that supposedly isn't alive - become sick?" It may be an important question because the oceans seem to be full of giant viruses such as the Mimivirus. These viruses may be common infectious agents of ocean plankton, even as they also serve as hosts to smaller infectious virophages. Thus the tiny virophage and the larger Mimivirus may affect plankton populations, which in turn affect ocean nutrients, fish populations and climate. If these novel viruses play a role in ecology they also may have played a role in evolution.

One of the obvious distinctions between our cells and bacterial cells - besides size- is complexity. Our cells have numerous organelles (tiny organs), and a discrete nucleus filled with DNA. Some of these organelles, such as the energy-producing mitochondria or plant chloroplasts responsible for photosynthesis, probably evolved from primitive bacteria that got into primitive cells and decided to stay. But where did the cell's DNA-filled nucleus come from? One theory suggests the nucleus evolved from large, infecting DNA viruses such as Mimivirus. But the opposite may be just as likely: that a lost nucleus devolved into the various DNA viruses we find today. The idea that our cells evolved from primitive infecting bacteria and viruses is interesting biology, but it also may have some implications for disease. If our cells' mitochondria are the remnants of primitive bacteria, could the become infected by an exotic virus in the same way phage viruses infect bacteria? At least one such mitochondria virus (mitovirus) has been found in the fungus that causes Dutch elm disease. Could similar mitoviruses be found infecting human mitochondria and causing unexplained degenerative diseases? "These kinds of microorganisms should be kept in mind for the future," wrote the editor of the MicrobiologyBytes blog. Good advice, because we know big fleas have little fleas, and big viruses have little viruses, and so, ad infinitum.

---

Dr. Edward McSweegan has a Ph.D. in microbiology and lives in Crofton. He

works on and writes about infectious disease issues. He may be contacted at

mcsweegan@nasw.org