Selected publications:

1. Brouwer, K., Evers, R., Hayden, E., Hu, S., Li, C., Meyer zu Schwabedissen, H., Neuhoff, S., Oswald, S., Piquette-Miller, M., Saran, C., Sjostedt, N., Sprowl, J., Stahl, S., and Yue, W., Regulation of Drug Transport Proteins - From Mechanisms to Clinical Impact; A White Paper on Behalf of the ITC, Clinical Pharmacology & Therapeutics, 2022, 112: 461, PMID: 35390174, PMCID: PMC9398928

2. Farasyn, T., Pahwa, S, Xu, C., and Yue, W., Pre-incubation with OATP1B1 and OATP1B3 inhibitors potentiates inhibitory effects in physiologically relevant sandwich-cultured primary human hepatocytes, European Journal of Pharmaceutical Sciences, 2021, 165: 105951, PMID: 34311070.

3. Farasyn, T., Xu, C., and Yue, W., Development of a primary rat sandwich-cultured hepatocytes model expressing functional human organic anion transporting polypeptide (OATP) 1B3: a novel tool to assess hepatobiliary disposition of human OATP1B3 substrates, Journal of Pharmacy and Pharmaceutical Sciences, 2021, 24: 475-483, PMID: 34516949

4. Kayesh, R., Farasyn, T., Crowe, A. Liu, Q., Pahwa, S., Alam, K., Neuhoff, S., Hatley, O., Ding, K. and Yue, W., Assessing OATP1B1- and OATP1B3-mediated drug-drug interaction potential of vemurafenib using R-value and physiologically based pharmacokinetic models, Journal of Pharmaceutical Sciences, 2021, 110: 314, PMID: 32590030, PMCID: PMC7750294

5. Crowe, A., Yue, W., Semi-quantitative determination of protein expression using immunohistochemistry staining and analysis: an integrated protocol, Bio Protocol, 2019, 9 (24) e3465, PMID: 31867411, PMCID: PMC6924920

6. Farasyn, T., Crowe, A., Hatley, O., Neuhoff, S., Alam, K. ‡, Kanyod, J., Lam, T., Ding, K. and Yue, W., Preincubation with everolimus and sirolimus reduces organic anion transporting polypeptide (OATP)1B1- and 1B3-mediated transport independently of mTOR kinase inhibition: implication in assessing OATP1B1- and OATP1B3-mediated drug-drug interactions, J Pharm Sci., 2019, 108 (10): 3443-3456, PMID: 31047942, PMCID: PMC6759397

7. Crowe, A., Miller, J., Yue, W., Genotyping of the OATP1B1 c. 521 T>C polymorphism from the Formalin-Fixed Paraffin-Embedded (FFPE) tissue specimens: an optimized protocol, Bio-Protocol, 2019, 9(16): e3343. PMID: 31840034, PMCID: PMC6909936

8. Crowe, A., Zheng, W., Miller, J., Pahwa, S., Alam, K., Fung, K., Rubin, E., Yin, F., Ding, K., Yue, W., Characterization of plasma membrane localization and phosphorylation status of organic anion transporting polypeptide (OATP) 1B1 c.521 T>C polymorphism, Pharm Res, 2019, 36: 101 (Cover image in 2019 July issue), PMID: 31093828

9. Alam, K., Farasyn, T., Ding, K., Yue, W., Characterization of liver- and cancer-type-organic anion transporting polypeptide (OATP) 1B3 messenger RNA expression in normal and cancerous human tissues, Drug Metabolism Letters, 2018, 12:24-32, PMID: 29577869, PMCID: PMC6133766

10. Alam, K., Crowe, A., Wang, X. Zhang, X., Ding, K., Li, L., Yue, W., Regulation of organic anion transporting polypeptides (OATP) 1B1- and OATP1B3-mediated transport: an updated review in the context of OATP-mediated drug-drug interactions, International Journal of Molecular Sciences, 2018,19: 855, PMCID: PMC5877716

11. Alam, K., Farasyn, T., Crowe, A., Ding, K., and Yue, W. Treatment with Proteasome Inhibitor Bortezomib Decreases Organic Anion Transporting Polypeptide (OATP) 1B3-Mediated Transport in a Substrate-Dependent Manner, Public Library of Science ONE, 2017, 12:11 e0186924, PMID: 29107984, PMCID: PMC5673231

12. Pahwa, S., Alam, K., Crowe, A., Farasyn, T., Neuhoff, S., Hatley, O., Ding, K., and Yue W., Pretreatment With Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated Transport, Journal of Pharmaceutical Sciences, 2017, 106: 2123, PMID: 28373111, PMCID: 5511785

13. Alam, K., Pahwa, S., Wang, X., Zhang, P., Ding, K., Abuznait, A., Li L., and Yue W., Down-Regulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implications in OATP-Mediated Drug-Drug Interactions, Molecular Pharmaceutics, 2016, 13:839-51, PMID: 26750564, PMCID: PMC4970216

14. Powell, J., Farasyn, T., Kock, K., Meng, X., Pahwa, S., Brouwer, K.L.R., Yue, W., Novel mechanism of impaired function of organic anion transporting polypeptide (OATP) 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation, Drug Metabolism and Disposition, 2014, 42:1964-1970. PMID: 25200870, PMCID: PMC4201128

15. Yang, K., Pfeifer, N., Hardwick, R., Yue, W., Stewart, P., Brouwer, K. L. R., An Experimental Approach to Evaluate the Impact of Impaired Transport Function on Hepatobiliary Drug Disposition Using Mrp2-Deficient TR- Rat Sandwich-Cultured Hepatocytes in Combination with Bcrp Knockdown, Molecular Pharmaceutics, 2014, 11: 766-775. PMID: 24410402 PMCID: PMC3993909

16. Bheda, A., Yue, W., Gullapalli, A., Shackelford, J. Pagano, J. S., PU.1-Dependent Regulation of UCH L1 Expression in B-lymphoma Cells, Leukemia and Lymphoma, 2011, 52:1336-1347. PMID: 21504384

17. Marion, T. L., Perry, C. H., St Claire, R. L., Yue, W., Brouwer, K. L. R., Differential Disposition of Chenodeoxycholic Acid versus Taurocholate Acid in Response to Acute Troglitazone Exposure in Rat Hepatocytes, Toxicological Science, 2011, 120:371-380. PMID: 21262925

18. Yue, W., Lee, J., Abe, K., Brouwer, K. L. R., Decreased hepatic Breast Cancer Resistance Protein Expression and Function in Multidrug Resistance-Associated Protein 2-Deficient TR- Rats, Drug Metabolism and Disposition, 2011, 39: 441-447. PMID: 21106720

19. Swift, B., Yue, W., Brouwer, K. L., Evaluation of (99m)Technetium-Mebrofenin and (99m)Technetium-Sestamibi as Specific Probes for Hepatic Transport Protein Function in Rat and Human Hepatocytes, Pharmaceutical Research, 2010, 27:1987. PMID: 20652625 PMCID: PMC3129651

20. Yue, W., Abe, K., Brouwer, K. L., Knocking Down Breast Cancer Resistance Protein (Bcrp) by Adenoviral Vector-Mediated RNA Interference (RNAi) in Sandwich-Cultured Rat Hepatocytes: a Novel Tool to Assess the Contribution of Bcrp to Drug Biliary Excretion, Molecular Pharmaceutics, 2009, 6: 134-143. PMCID: PMC3135650

21. Bheda, A., Yue, W., Gullapalli, A., Whitehurst, C., Liu, R., Pagano, J. S., Shackelford, J., Positive Reciprocal Regulation of Ubiquitin C-Terminal Hydrolase L1 and beta-Catenin/TCF Signaling, Public Library of Science ONE, 2009, 4: e5955. PMCID: PMC2694282

22. Abe, K., Bridges, A. S., Yue, W. and Brouwer, K. L., In Vitro Biliary Clearance of Angiotensin II Receptor Blockers and HMG-CoA Reductase Inhibitors in Sandwich-Cultured Rat Hepatocytes: Comparison to In Vivo Biliary Clearance, Journal of Pharmacology and Experimental Therapeutics, 2008, 326: 983-990. PMCID: PMC2581923

23. Yue, W., Shackelford, J., Pagano, J. S., Cdc2/cyclin B1-Dependent Phosphorylation of EBNA2 at Ser243 Regulates Its Function in Mitosis, Journal of Virology, 2006, 80: 2045-2050. PMCID: PMC1367142

24. Yue, W., Gershburg, E., Pagano, J. S., Hyperphosphorylation of EBNA2 by Epstein-Barr Virus Protein Kinase Suppresses Transactivation of the LMP1 Promoter, Journal of Virology, 2005, 79: 5880-5885. PMCID: PMC1082719

25. Yue, W., Davenport, M. G., Shackelford, J., Pagano, J. S., Mitosis-Specific Hyperphosphorylation of the Epstein-Barr Virus Nuclear Antigen-2 (EBNA-2) Suppresses Its Function, Journal of Virology, 2004, 78: 3542-3552. PMCID: PMC371044