Current Members and Alumni

Publications:

• Powell, J., Kayesh, R., Ballesteros-Perez, A., Alam, K., Niyonshuti, P., Soderblom, E., Ding, K., Xu, C., and Yue, W., Assessing trans-inhibition of OATP1B1 and OATP1B3 by calcineurin and/or PPIase inhibitors and global identification of OATP1B1/3-associated proteins, Pharmaceutics, 2024, 16:63

Presentations:

• 2023 Graduate Research Education and Technology Debate Session, March 2023

Award:

• Undergraduate Creative Activities and Research Experiences (UCARE) Award ($4800): 2021-2022, University of Nebraska-Lincoln. 

Publications:

• Powell, JT, Kayesh, R, Ballesteros-Perez, A, Alam, K, Niyonshuti, P, Soderblom, E, Ding, K, Xu, C, and Yue, W, Assessing trans-inhibition of OATP1B1 and OATP1B3 by calcineurin and/or PPIase inhibitors and global identification of OATP1B1/3-associated proteins, Pharmaceutics, 2024, 16:63

• Powell JT, Farasyn T, Köck K, Meng X, Pahwa S, Brouwer KLR, Yue W (2014). Novel Mechanism of Impaired Function of Organic Anion-Transporting Polypeptide 1B3 in Human Hepatocytes: Post-Translational Regulation of OATP1B3 by Protein Kinase C Activation. Drug Metab Dispos 42:1964-70.

• Powell JT, Akhuetie-Oni BO, Zhang Z, Lin C (2016). Structural Switching DNA Origami Rotaxanes. Angew Chemie 55:11412– 11416. 

• Sheikh MO, Schafer CM, Powell JT, Rodgers KK, Mooers BH, West CM (2014). Glycosylation of Skp1 affects its conformation and promotes binding to a model f-box protein. Biochemistry 53:1657-69.

• Xiong Q, Xie C, Zhang Z, Liu L, Powell JT, Q Shen, C Lin (2020). DNA Origami Post‐Processing by CRISPR‐Cas12a. Angew Chemie 59:3956-3960.

• Williams ND, Landajuela A, Kasula RK, Zhou W, Powell JT, Xi Z, Isaacs FJ, Berro J, Toomre D, Karatekin E, Lin C (2020). DNA-Origami-Based Fluorescence Brightness Standards for Convenient and Fast Protein Counting in Live Cells. Nano Letters 20:8890-8896.

Awards

• National Science Foundation (NSF) Graduate Research Fellowship: 2015-2020

• OUHSC Stephenson Cancer Center Postdoctoral Travel Award: 2023

Selected Publications:

• Kayesh, R., Tambe, V., Xu, C., and Yue, W., Differential Preincubation Effects of Nicardipine on OATP1B1- and OATP1B3-Mediated Transport in the Presence and Absence of Protein: Implications in Assessing OATP1B1- and OATP1B3-Mediated Drug–Drug Interactions, Pharmaceutics 2023, 15(3), 1020

• Tambe, V., Patel, S., Shard, A., Behera, S. K., Polaka, S., Anup, N., Gadeval, A., Kalia, K. & Tekade, R. K. Dendronized Polymeric Biomaterial for Loading, Stabilization, and Targeted Cytosolic Delivery of microRNA in Cancer Cells, ACS Applied Bio Materials 2022, 5: 4128-4153. (Front cover of the journal in September 2022 Issue).

• Tambe, V.; Raval, N.; Gondaliya, P.; Bhattacharya, P.; Kalia, K.; Tekade, R. K. To investigate fit-to-purpose nanocarrier for non-invasive drug delivery to posterior segment of eye, Journal of drug delivery science and technology, 2021, 61: 102222.

• Tambe V, Thakkar S, Raval N, Sharma D, Kalia K, Tekade RK. Surface Engineered Dendrimers in siRNA Delivery and Gene Silencing. Curr Pharm Des. 2017, 23:2952-2975.

• Pradhan, D.; Tambe, V.; Raval, N.; Gondalia, P.; Bhattacharya, P.; Kalia, K.; Tekade, R. K. Dendrimer grafted albumin nanoparticles for the treatment of post cerebral stroke damages: A proof of concept study, Colloids and Surfaces B: Biointerfaces, 2019, 184:110488. PMID 31541894

• Raval N, Gondaliya P, Tambe V, Kalia K, Tekade RK., Engineered nanoplex mediated targeted miRNA delivery to rescue dying podocytes in diabetic nephropathy, Int J Pharm. 2021, 605:120842. PMID: 34216766

Awards

• Senior Research Fellowship by Indian Council of Medical Research (ICMR): 2019-2022

Publication:

• Kayesh, R., Tambe, V., Xu, C., and Yue, W., Differential Preincubation Effects of Nicardipine on OATP1B1- and OATP1B3-Mediated Transport in the Presence and Absence of Protein: Implications in Assessing OATP1B1- and OATP1B3-Mediated Drug–Drug Interactions, Pharmaceutics 2023, 15(3), 1020

• Kayesh, R., Farasyn, T., Crowe, A, Liu, Q., Pahwa, S., Alam, K., Neuhoff, S., Hatley, O., Ding, K. and Yue, W., Assessing OATP1B1- and OATP1B3-mediated drug-drug interaction potential of vemurafenib using R-value and physiologically based pharmacokinetic models, Journal of Pharmaceutical Sciences, 2021, 110: 314, PMID: 32590030, PMCID: PMC7750294

Presentations:

• Kayesh, R.; Farasyn, T.; Crowe, A.; Liu, Q.; Pahwa, S.; Alam, K.; Neuhoff, S.; Hatley, O.; Ding, K.; Yue, W., Assessing OATP1B1- and OATP1B3-mediated drug-drug interaction potential of vemurafenib by applying the total IC50 approach in R-value and physiologically-based pharmacokinetic models, Clinical Pharmacology & Therapeutics, 2021, 109: Suppl S1, ITCW-007), International Transporter Consortium Workshop 4 (ITCW4), April 19-21, 2021 (Stephenson Cancer Center OUHSC Trainee Research Conference and Workshop Award)

• Kayesh, R., Farasyn, T., Crowe, A., Liu, Q., Pahwa, S., Alam, K., Ding  K., Neuhoff, S., Hatley, O., Yue, W., Assessing OATP1B1- and OATP1B3-mediated drug-drug interaction potential of vemurafenib using static and physiologically based pharmacokinetic models, PharmSci 360-AAPS Annual Meeting San Antonio, Texas, Nov. 3-6, 2019 (Harris Travel Award OUHSC)

Publications:

• Alam, K., Farasyn, T., Ding, K., Yue, W., Characterization of liver- and cancer-type-organic anion transporting polypeptide (OATP) 1B3 messenger RNA expression in normal and cancerous human tissues, Drug Metabolism Letters, 2018, 12:24-32, PMID: 29577869, PMCID: PMC6133766

•  Alam, K., Crowe, A., Wang, X. Zhang, X., Ding, K., Li, L., Yue, W., Regulation of organic anion transporting polypeptides (OATP) 1B1- and OATP1B3-mediated transport: an updated review in the context of OATP-mediated drug-drug interactions, International Journal of Molecular Sciences, 2018,19: 855, PMCID: PMC5877716

• Alam, K., Farasyn, T., Crowe, A., Ding, K., and Yue, W. Treatment with Proteasome Inhibitor Bortezomib Decreases Organic Anion Transporting Polypeptide (OATP) 1B3-Mediated Transport in a Substrate-Dependent Manner, Public Library of Science ONE, 2017, 12:11 e0186924, PMID: 29107984, PMCID: PMC5673231

• Pahwa, S., Alam, K., Crowe, A., Farasyn, T., Neuhoff, S., Hatley, O., Ding, K., and Yue W., Pretreatment With Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated Transport, Journal of Pharmaceutical Sciences, 2017, 106: 2123, PMID: 28373111, PMCID: 5511785

• Alam, K., Pahwa, S., Wang, X., Zhang, P., Ding, K., Abuznait, A., Li L., and Yue W., Down-Regulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implications in OATP-Mediated Drug-Drug Interactions, Molecular Pharmaceutics, 2016, 13:839-51, PMID: 26750564, PMCID: PMC4970216

Presentations:

• Alam, K., Wang, X., Zhang, P., Ding, K., Li, L., and Yue, W., Down-Regulation of OATP1B3 transport function by proteasome inhibitor bortezomib, American Association of Pharmaceutical Scientists (AAPS) Annual Meeting, Denver, CO, Nov. 2016

• Alam, K., Crowe, A., Pahwa, S., and Yue, W., Altered Phosphorylation Status of OATP1B1 and 1B3 is Associated with Decreased Transport Function Following Cyclosporine A Treatment, Drug Metabolism Gordon Research Conference, Holderness, NH, July, 2016 (GRC Sponsored Presentation)

• Alam, K., Alaa, A., Pahwa, S., Ding, K. and Yue, W., Indirect inhibition of organic anion transporting polypeptide (OATP) 1B1-mediated transport by lysosome inhibitor chloroquine, American Association of Pharmaceutical Scientists (AAPS)/International Transport Consortium (ITC) Joint Workshop on Drug Transporters, Baltimore, MD, April 20-22, 2015

• Alam, K., Zhang, W., Fung, K., and Yue, W., Expression of liver- and cancer-type OATP1B3 in Cancer and non-malignant tissues. The Graduate Research Education and Technology Symposium (GREAT) of OUHSC, OKC, 2016, March 28-March 31, 2016

• Alam, K., Zhang, W., Fung, K., and Yue, W., Expression of liver- and cancer-type OATP1B3 in Cancer and non-malignant tissues. The Stephenson Cancer Center Research Symposium OUHSC, Oklahoma City, Jan.  29, 2016

• Alam, K., Alaa, A., Pahwa, S., Ding, K. and Yue, W., Indirect inhibition of organic anion transporting polypeptide (OATP) 1B1-mediated transport by lysosome inhibitor chloroquine, The Graduate Research Education and Technology Symposium (GREAT) of OUHSC, OKC, 2015, March 30-April 2, 2015

• Alam, K., Powell, J., Ding, K. and Yue, W., Indirect inhibition of organic anion transporting polypeptide (OATP) 1B3-mediated transport by proteasome inhibitor bortezomib, The Stephenson Cancer Center Research Symposium OUHSC,  Oklahoma City, Jan. 2015

• Alam, K., Powell, J., Ding, K., and Yue, W., Inhibition of organic anion transporting polypeptide (OATP) 1B3-mediated drug transport by proteasome inhibitor bortezomib: implications in cancer therapy, The Stephenson Cancer Center Research Symposium OUHSC,  Oklahoma City, Jan. 2015

• Alam, K., Abuznait, A., and Yue, W., Down-regulation of organic anion transporting polypeptide (OATP) 1B3 function by proteasome inhibitor bortezomib, The Graduate Research Education and Technology Symposium (GREAT), OUHSC, 2014

• Alam, K., Abuznait, A., Yue, W., Down-regulation of organic anion transporting polypeptide (OATP) 1B3 function by proteasome inhibitor bortezomib, The Stephenson Cancer Center Research Symposium OUHSC,  Oklahoma City, Jan. 2014

Publications:

• Farasyn, T., Pahwa, S., Xu, C., and Yue, W., Pre-incubation with OATP1B1 and OATP1B3 inhibitors potentiates inhibitory effects in physiologically relevant sandwich-cultured primary human hepatocytes, European Journal of Pharmaceutical Sciences, 2021, 165: 105951, PMID: 34311070.

•  Farasyn, T., Xu, C., and Yue, W., Development of a primary rat sandwich-cultured hepatocytes model expressing functional human organic anion transporting polypeptide (OATP) 1B3: a novel tool to assess hepatobiliary disposition of human OATP1B3 substrates, Journal of Pharmacy and Pharmaceutical Sciences, 2021, 24: 475-483, PMID: 34516949

• Kayesh, R., Farasyn, T., Crowe, A., Liu, Q., Pahwa, S., Alam, K., Neuhoff, S., Hatley, O., Ding, K. and Yue, W., Assessing OATP1B1- and OATP1B3-mediated drug-drug interaction potential of vemurafenib using R-value and physiologically based pharmacokinetic models, Journal of Pharmaceutical Sciences, 2021, 110: 314, PMID: 32590030, PMCID: PMC7750294

• Farasyn, T., Crowe, A., Hatley, O., Neuhoff, S., Alam, K., Kanyod, J., Lam, T., Ding, K. and Yue, W., Preincubation with everolimus and sirolimus reduces organic anion transporting polypeptide (OATP)1B1- and 1B3-mediated transport independently of mTOR kinase inhibition: implication in assessing OATP1B1- and OATP1B3-mediated drug-drug interactions, J Pharm Sci., 2019, 108 (10): 3443-3456, PMID: 31047942, PMCID: PMC6759397

• Alam, K., Farasyn, T., Ding, K., Yue, W., Characterization of liver- and cancer-type-organic anion transporting polypeptide (OATP) 1B3 messenger RNA expression in normal and cancerous human tissues, Drug Metabolism Letters, 2018, 12:24-32, PMID: 29577869, PMCID: PMC6133766

• Alam, K., Farasyn, T., Crowe, A., Ding, K., and Yue, W. Treatment with Proteasome Inhibitor Bortezomib Decreases Organic Anion Transporting Polypeptide (OATP) 1B3-Mediated Transport in a Substrate-Dependent Manner, Public Library of Science ONE, 2017, 12:11 e0186924, PMID: 29107984, PMCID: PMC5673231

• Pahwa, S., Alam, K., Crowe, A., Farasyn, T., Neuhoff, S., Hatley, O., Ding, K., and Yue W., Pretreatment With Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated Transport, Journal of Pharmaceutical Sciences, 2017, 106: 2123, PMID: 28373111, PMCID: 5511785

• Powell, J., Farasyn, T., Kock, K., Meng, X., Pahwa, S., Brouwer, K.L.R., Yue, W., Novel mechanism of impaired function of organic anion transporting polypeptide (OATP) 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation, Drug Metabolism and Disposition, 2014, 42:1964-1970. PMID: 25200870, PMCID: PMC4201128

Presentations:

• Farasyn, T., Alam, K., Crowe, A., Neuhoff, S., Hatley, O.,  Wang, X., Zhang, P., Ding, K., Li, L. and Yue, W., Assessing the OATP1B1- and OATP1B3-mediated drug-drug interaction potential of mammalian target of rapamycin (mTOR) inhibitor everolimus, Drug Metabolism and Pharmacokinetics, 2018, 33 (S1): S48 at 21st North American International Society for the Study of Xenobiotics (ISSX), Providence, RI, Sept., 2017

• Farasyn, T., Alam, K., Crowe, A., Neuhoff, S., Hatley, O.,  Wang, X., Zhang, P., Ding, K., Li, L. and Yue, W., Down-Regulation of OATP1B1-Mediated Transport by Mammalian Target of Rapamycin (mTOR) Inhibitors Everolimus and Sirolimus: Potential Mechanism and Implication in OATP-Mediated Drug-Drug Interactions, The FASEB Journal, 2017, 31 (S1) at Experimental Biology Meeting, Chicago, IL, April, 2017

• Farasyn, T., Powell, J., Ding, K., Yue, W., Rapid down-regulation of organic anion transporting polypeptide (OATP) 1B3 transport function by phosphorylation modulators in sandwich-cultured hepatocytes: a novel mechanism of OATP1B3 inhibition, Drug Metab Rev. 2015, 47(S1): 259, 19th North American ISSX and 29th JSSX Meeting San Francisco, CA, Oct. 19-23, 2014

• Farasyn, T., Pahwa, S., Kayesh, R., Alam, K., Ding, K., Yue, W., Assessing OATP1B1- and OATP1B3-mediated drug-drug interaction potential of vemurafenib using static and physiologically based pharmacokinetic models, American Association of Pharmaceutical Scientists (AAPS)/International Transport Consortium (ITC) Joint Workshop on Drug Transporters in ADME: From the bench to the bedside, Dulles, VA, April 16-18, 2018 (Selected for Poster podium presentation among total of 6 being selected)

• Farasyn, T., Alam, K., Crowe, A., Neuhoff, S., Hatley, O.,  Wang, X., Zhang, P., Ding, K., Li, L. and Yue, W., Multidisciplinary approach assessing OATP-mediated Drug Drug Interaction Potential of Everolimus, Drug Metabolism Gordon Research Conference, Holderness, NH, July, 2017

• Farasyn, T., Wang, X., Zhang, P., Alam, K., Pahwa, S., Ding, K., Li, L., and Yue, W., Down-Regulation of OATP1B1 and 1B3 Transport Function by mTOR inhibitors Everolimus and Sirolimus: Potential Mechanism and Implications in OATP-Mediated Drug-Drug Interactions, , Drug Metabolism Gordon Research Conference, Holderness, NH, July, 2016

• Farasyn, T., Pahwa, S., Ding, K., Alam, K., and Yue, W., Rapid Down-Regulation of Organic Anion Transporting Polypeptide (OATP) 1B1 and 1B3 Transport Function by Mammalian Target of Rapamycin (mTOR) Inhibitor Sirolimus, American Association of Pharmaceutical Scientists (AAPS)/International Transport Consortium (ITC) Joint Workshop on Drug Transporters, Baltimore, MD, April 20-22, 2015 (Travel Award, Oral and poster podium presentation)

• Farasyn, T., Powell, J., Köck, K., Meng, X., Pahwa, S., Brouwer, K.L.R., and Yue, W., Post-translational regulation of organic anion transporting polypeptide (OATP)1B3 function by protein kinase C activation: a novel mechanism of hepatic OATP1B3 inhibition, Drug Metabolism Gordon Conference, Holderness, NH, July, 2014

• Farasyn, T., Pahwa, S., Ding, K. and Yue, W., Rapid Down-Regulation of Organic Anion Transporting Polypeptide (OATP) 1B1 and 1B3 Transport Function by Mammalian Target of Rapamycin (mTOR) Inhibitor Sirolimus, The Graduate Research Education and Technology Symposium (GREAT) of OUHSC, OKC, 2015, March 30-April 2, 2015

Publications:

• Kayesh, R., Farasyn, T., Crowe, A., Liu, Q., Pahwa, S., Alam, K., Neuhoff, S., Hatley, O., Ding, K. and Yue, W., Assessing OATP1B1- and OATP1B3-mediated drug-drug interaction potential of vemurafenib using R-value and physiologically based pharmacokinetic models, Journal of Pharmaceutical Sciences, 2021, 110: 314, PMID: 32590030, PMCID: PMC7750294

• Crowe, A., Yue, W., Semi-quantitative Determination of Protein Expression using Immunohistochemistry Staining and Analysis: An Integrated Protocol, Bio Protocol, 2019, 9 (24) e3465, PMID: 31867411, PMCID: PMC6924920

• Crowe, A., Zheng, W., Miller, J., Pahwa, S., Alam, K., Fung, K., Rubin, E., Yin, F., Ding, K., Yue, W., Characterization of plasma membrane localization and phosphorylation status of organic anion transporting polypeptide (OATP) 1B1 c.521 T>C polymorphism, Pharm Res, 2019, 36: 101 (Cover image in 2019 July issue), PMID: 31093828

• Alam, K., Crowe, A., Wang, X. Zhang, X., Ding, K., Li, L., Yue, W., Regulation of organic anion transporting polypeptides (OATP) 1B1- and OATP1B3-mediated transport: an updated review in the context of OATP-mediated drug-drug interactions, International Journal of Molecular Sciences, 2018,19: 855, PMCID: PMC5877716

• Alam, K., Farasyn, T., Crowe, A., Ding, K., and Yue, W. Treatment with Proteasome Inhibitor Bortezomib Decreases Organic Anion Transporting Polypeptide (OATP) 1B3-Mediated Transport in a Substrate-Dependent Manner, Public Library of Science ONE, 2017, 12:11 e0186924, PMID: 29107984, PMCID: PMC5673231

• Pahwa, S., Alam, K., Crowe, A., Farasyn, T., Neuhoff, S., Hatley, O., Ding, K., and Yue W., Pretreatment With Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated Transport, Journal of Pharmaceutical Sciences, 2017, 106: 2123, PMID: 28373111, PMCID: 5511785

Presentations:

• Crowe, A., Zheng, W., Miller, J., Alam, K., Fung, K., Rubin, E., Yin, F., Ding, K., and Yue, W., Characterization of plasma membrane localization and phosphorylation status of organic anion transporting polypeptide (OATP) 1B1 c.521 T>C polymorphism, PharmSci 360-American Association of Pharmaceutical Scientists Annual Meeting, Washington DC, Nov. 4-7, 2018. [Crowe received AAPS travel ship and the Best Abstract Award]

• Crowe, A., Alam, K., Pahwa, S., and Yue, W., Altered Phosphorylation Status of OATP1B1 and 1B3 is Associated with Decreased Transport Function Following Cyclosporine A Treatment, American Association of Pharmaceutical Scientists (AAPS) Annual Meeting, Denver, CO, Nov. 2016

Publications:

• Pahwa, S., Alam, K., Crowe, A., Farasyn, T., Neuhoff, S., Hatley, O., Ding, K., and Yue W., Pretreatment With Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated Transport, Journal of Pharmaceutical Sciences, 2017, 106: 2123, PMID: 28373111, PMCID: 5511785

• Farasyn, T., Pahwa, S., Xu, C., and Yue, W., Pre-incubation with OATP1B1 and OATP1B3 inhibitors potentiates inhibitory effects in physiologically relevant sandwich-cultured primary human hepatocytes, European Journal of Pharmaceutical Sciences, 2021, 165: 105951, PMID: 34311070.

• Alam, K., Pahwa, S., Wang, X., Zhang, P., Ding, K., Abuznait, A. ‡, Li L., and Yue W., Down-Regulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implications in OATP-Mediated Drug-Drug Interactions, Molecular Pharmaceutics, 2016, 13:839-51, PMID: 26750564, PMCID: PMC4970216

• Kayesh, R., Farasyn, T., Crowe, A., Liu, Q., Pahwa, S., Alam, K., Neuhoff, S., Hatley, O., Ding, K. and Yue, W., Assessing OATP1B1- and OATP1B3-mediated drug-drug interaction potential of vemurafenib using R-value and physiologically based pharmacokinetic models, Journal of Pharmaceutical Sciences, 2021, 110: 314, PMID: 32590030, PMCID: PMC7750294

• Crowe, A., Zheng, W., Miller, J., Pahwa, S., Alam, K., Fung, K., Rubin, E., Yin, F. ‡, Ding, K., Yue, W., Characterization of plasma membrane localization and phosphorylation status of organic anion transporting polypeptide (OATP) 1B1 c.521 T>C polymorphism, Pharm Res, 2019, 36: 101 (Cover image in 2019 July issue), PMID: 31093828

• Powell, J., Farasyn, T., Kock, K., Meng, X., Pahwa, S., Brouwer, K.L.R., Yue, W., Novel mechanism of impaired function of organic anion transporting polypeptide (OATP) 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation, Drug Metabolism and Disposition, 2014, 42:1964-1970. PMID: 25200870, PMCID: PMC4201128

Presentations:

• Pahwa, S., Farasyn, T., Alam, K., Crowe, A., Ding, K., and Yue, W., Pretreatment with Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated Transport, American Association of Pharmaceutical Scientists (AAPS) Annual Meeting, Denver, CO, Nov. 2016

• Pahwa, S., Alam, K., Woo, S. and Yue, W., Pre-Incubation Potentiates the Inhibitory Effects of Tyrosine Kinase Inhibitors toward OATP1B1- and 1B3-Mediated Transport, American Association of Pharmaceutical Scientists (AAPS)/International Transport Consortium (ITC) Joint Workshop on Drug Transporters, Baltimore, MD, April 20-22, 2015

• Pahwa, S. and Yue, W., Can cancer patients safely take kinase inhibitor drugs and statins together? Prediction of OATP-mediated drug-drug interactions of TKIs against rosuvastatin, Drug Metabolism Gordon Conference, Holderness, NH, July, 2014 (GRC Sponsored Presentation)

• Pahwa, S. and Yue, W., Can cancer patients safely take kinase inhibitor drugs and statins together? The Graduate Research Education and Technology Symposium (GREAT) of OUHSC, 2014 (Oral presentation competition)

• Pahwa, S., Powell, J., and Yue, W. Regulation of organic anion transporting polypeptides by tyrosine kinase inhibitors, The Stephenson Cancer Center Research Symposium OUHSC,  Oklahoma City, Jan. 2014

Publication:

• Alam, K., Pahwa, S., Wang, X., Zhang, P., Ding, K., Abuznait, A., Li L., and Yue W., Down-Regulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implications in OATP-Mediated Drug-Drug Interactions, Molecular Pharmaceutics, 2016, 13:839-51, PMID: 26750564, PMCID: PMC4970216

Presentation:

• Abuznait, A., Powell, J., Girton M., Yue, W., Regulation of OATP1B1 degradation and trafficking via ubiquitin-proteasome pathway, The Stephenson Cancer Center Research Symposium OUHSC,  Oklahoma City, Jan. 2014 

Publication:

• Powell, J., Farasyn, T., Kock, K., Meng, X., Pahwa, S., Brouwer, K.L.R., Yue, W., Novel mechanism of impaired function of organic anion transporting polypeptide (OATP) 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation, Drug Metabolism and Disposition, 2014, 42:1964-1970. PMID: 25200870, PMCID: PMC4201128

Presentation:

• Meng, X., Köck, K., Li, J., Kim L. R. Brouwer and Yue, W., Protein kinase C activation rapidly down-regulates OATP1B3 transport function in primary human hepatocytes, American Association of Pharmaceutical Scientists (AAPS) Annual Meeting, San Antonio, Nov. 2013

Publication:

• Powell, J., Farasyn, T., Kock, K., Meng, X., Pahwa, S., Brouwer, K.L.R., Yue, W., Novel mechanism of impaired function of organic anion transporting polypeptide (OATP) 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation, Drug Metabolism and Disposition, 2014, 42:1964-1970. PMID: 25200870, PMCID: PMC4201128

Publications:

• Crowe, A., Miller, J., Yue, W., Genotyping of the OATP1B1 c. 521 T>C polymorphism from the Formalin-Fixed Paraffin-Embedded (FFPE) tissue specimens: an optimized protocol, Bio-Protocol, 2019, 9(16): e3343. PMID: 31840034, PMCID: PMC6909936

•  Crowe, A. , Zheng, W., Miller, J. , Pahwa, S. , Alam, K. , Fung, K., Rubin, E., Yin, F. ‡, Ding, K., Yue, W., Characterization of plasma membrane localization and phosphorylation status of organic anion transporting polypeptide (OATP) 1B1 c.521 T>C polymorphism, Pharm Res, 2019, 36: 101 (Cover image in 2019 July issue), PMID: 31093828