GAG and Protein Interaction (Mr. Vedaprakash Panda)

Glycosaminoglycans (GAGs) are extensive direct polysaccharides built of repeating disaccharide units with the essential designs containing an amino sugar (either GlcNAc or GalNAc) and an uronic acid (either glucuronic acid and/or iduronic acid). There are five recognized GAG chains such as Hyaluronan, Chondroitin, Dermatan, Heparin and Kertan. GAGs are highly polar and attract water which are involved in many important biological processes. As the main unsulfated GAG, hyaluronic acid (HA) is involved pair disaccharide rehashes of β-1,4-d-glucuronic acid and β-1,3-d-N-acetylglucosamine. Organic investigations of HA are accepting expanded premiums because of their mediatory parts in cell adhesion, cell migration, innate immunity and wound healing. Heparin and heparin sulphate (H/HS) are highly charged, involved in regulating a wide range of biologically functions, including angiogenesis.

In this context, we have designed to synthesize all possible types of GAGs and elucidate GAG-protein interactions with different approaches as well as a molecular-level understanding of those complexes.