Lab Members and Alumni

Vishakha Tambe (Postdoctoral Fellow, 2022-present), received MS Pharm in 2017 and PhD degree in 2022 in Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research at Ahmedabad (NIPER-A), India. Dr. Tambe joined the Yue lab in Dec. 2022.

Selected Prior Publications:

  • Tambe, V., Patel, S., Shard, A., Behera, S. K., Polaka, S., Anup, N., Gadeval, A., Kalia, K. & Tekade, R. K. Dendronized Polymeric Biomaterial for Loading, Stabilization, and Targeted Cytosolic Delivery of microRNA in Cancer Cells, ACS Applied Bio Materials 2022, 5: 4128-4153. (Front cover of the journal in September 2022 Issue).

  • Tambe, V.; Raval, N.; Gondaliya, P.; Bhattacharya, P.; Kalia, K.; Tekade, R. K. To investigate fit-to-purpose nanocarrier for non-invasive drug delivery to posterior segment of eye, Journal of drug delivery science and technology, 2021, 61: 102222.

  • Tambe V, Thakkar S, Raval N, Sharma D, Kalia K, Tekade RK. Surface Engineered Dendrimers in siRNA Delivery and Gene Silencing. Curr Pharm Des. 2017, 23:2952-2975.

  • Pradhan, D.; Tambe, V.; Raval, N.; Gondalia, P.; Bhattacharya, P.; Kalia, K.; Tekade, R. K. Dendrimer grafted albumin nanoparticles for the treatment of post cerebral stroke damages: A proof of concept study, Colloids and Surfaces B: Biointerfaces, 2019, 184:110488. PMID 31541894

  • Raval N, Gondaliya P, Tambe V, Kalia K, Tekade RK., Engineered nanoplex mediated targeted miRNA delivery to rescue dying podocytes in diabetic nephropathy, Int J Pharm. 2021, 605:120842. PMID: 34216766

  • Patharkar, A.; Raval, N.; Kalyane, D.; Tambe, V.; Anup, N.; More, N.; Kapusetti, G.; Kalia, K.; Tekade, R. K. Glucosamine-conjugated nanoseeds for chemo-magneto hyperthermia therapy of cancer, Journal of Drug Delivery Science and Technology, 2021, 61:102295.

  • Muniswamy, V. J.; Raval, N.; Gondaliya, P.; Tambe, V.; Kalia, K.; Tekade, R. K, Dendrimer-Cationized-Albumin’encrusted polymeric nanoparticle improves BBB penetration and anticancer activity of doxorubicin, Int J Pharm.2019, 555:77-99

  • Todke, P., Polaka, S., Raval, N., Gondaliya, P., Tambe, V., Maheshwari, R., Kalia, K. & Tekade, R. K. ‘Transfersome-embedded-gel’ for dual-mechanistic delivery of anti-psoriatic drugs to dermal lymphocytess, Journal of Microencapsulation, 2022, 39: 495-511.

  • Mahajan, S.; Raval, N.; Kalyane, D.; Anup, N.; Maheshwari, R.; Tambe, V.; Kalia, K.; Tekade, R. K. NanoGold-core dendrimeric seeds for combined chemo, photothermal, and photodynamic therapy of cancer, Journal of Drug Delivery Science and Technology, 2020, 58:101814.

Book Chapters

  • Tambe, V.; Desai, N.; Rajpoot, K.; Tekade, R. K., “Organ-on-a-chip”-based physiologically relevant pharmacokinetic models. In Biopharmaceutics and Pharmacokinetics Considerations, 2021; pp 643-673. Doi- 10.1016/B978-0-12-814425-1.00024-3

  • Tambe, V.; Ditani, A.; Rajpoot, K.; Tekade, R. K., Pharmacokinetics aspects of structural modifications in drug design and therapy. In Biopharmaceutics and Pharmacokinetics Considerations, 2021; pp 83-108. Doi- 10.1016/B978-0-12-814425-1.00014-0

  • Tambe, V.; Kathar, U.; Raval, N.; Rajpoot, K.; Shilpi, S.; Khatri, K.; Tekade, R. K., Positron emission tomography as a noninvasive tool in pharmacokinetic studies. In Biopharmaceutics and Pharmacokinetics Considerations, 2021; pp 617-641. Doi-10.1016/B978-0-12-814425-1.00013-9

  • Tambe, V.; Pande, S.; Gadeval, A.; Rajpoot, K.; Raval, N.; Tekade, R. K., Microdialysis: an emerging technique for pharmacokinetic–pharmacodynamic profiling. In Biopharmaceutics and Pharmacokinetics Considerations, 2021; pp 601-616.Doi- 10.1016/B978-0-12-814425-1.00018-8

  • Tambe, V.; Shukla, H.; Rajpoot, K.; Pandey, M. M.; Tekade, R. K., Pharmacokinetics aspects of biotechnological products. In Biopharmaceutics and Pharmacokinetics Considerations, 2021; pp 539-565.Doi-https://doi.org/10.1016/B978-0-12-814425-1.00012-7

  • Tambe, V.; Sirsat, B.; Rajpoot, K.; Gadeval, A.; Tekade, R. K., Pharmacogenomics and drug metabolism. In Biopharmaceutics and Pharmacokinetics Considerations, 2021; pp 355-385.Doi- 10.1016/B978-0-12-814425-1.00021-8

  • Tambe, V.; Maheshwari, R.; Chourasiya, Y.; Choudhury, H.; Gorain, B.; Tekade, R. K., Clinical aspects and regulatory requirements for nanomedicines. In Basic fundamentals of drug delivery, 2019; pp 733-752. Doi-10.1016/B978-0-12-817909-3.00018-2

Ruhul Kayesh (PhD candidate 2017-present), received MS degree in Pharmaceutical Chemistry from University of Dhaka, Bangladesh in 2011. He joined the Yue lab in 2017.

Awards and Internship received:

  • E Blanche Sommers Scholarship Award ($2,500)-Outstanding Graduate Student in Pharmaceutical Sciences, OU College of Pharmacy, May 2022

  • Trainee Research Conference and Workshop Award ($500), to present research at the International Transporter Consortium Workshop 4 (ITCW4), April 19-21, 2021, Stephenson Cancer Center OUHSC, 2020

  • Loyd E. and Maurine Harris Travel Award ($1,000) to present research at 2019 AAPS/PharmSci 360, OU College of Pharmacy, 2019

  • Drug Metabolism Pharmacokinetic-Bioanalysis group of AbbVie Internship, May 23-Aug. 12, 2022 at AbbVie Inc., South San Francisco, CA

Publications and presentations from Yue Lab:

Publication:

  • Kayesh, R., Farasyn, T., Crowe, A, Liu, Q., Pahwa, S., Alam, K., Neuhoff, S., Hatley, O., Ding, K. and Yue, W., Assessing OATP1B1- and OATP1B3-mediated drug-drug interaction potential of vemurafenib using R-value and physiologically based pharmacokinetic models, Journal of Pharmaceutical Sciences, 2021, 110: 314, PMID: 32590030, PMCID: PMC7750294

Presentations:

  • Kayesh, R.; Farasyn, T.; Crowe, A.; Liu, Q.; Pahwa, S.; Alam, K.; Neuhoff, S.; Hatley, O.; Ding, K.; Yue, W., Assessing OATP1B1- and OATP1B3-mediated drug-drug interaction potential of vemurafenib by applying the total IC50 approach in R-value and physiologically-based pharmacokinetic models, Clinical Pharmacology & Therapeutics, 2021, 109: Suppl S1, ITCW-007), International Transporter Consortium Workshop 4 (ITCW4), April 19-21, 2021 (Stephenson Cancer Center OUHSC Trainee Research Conference and Workshop Award)

  • Kayesh, R., Farasyn, T., Crowe, A., Liu, Q., Pahwa, S., Alam, K., Ding K., Neuhoff, S., Hatley, O., Yue, W., Assessing OATP1B1- and OATP1B3-mediated drug-drug interaction potential of vemurafenib using static and physiologically based pharmacokinetic models, PharmSci 360-AAPS Annual Meeting San Antonio, Texas, Nov. 3-6, 2019 (Harris Travel Award OUHSC)

  • Kayesh, R., Xu, C. and Yue, W., Phosphorylation at serine S659 reduces transport Function of organic anion Transporting polypeptide (OATP) 1B1, PharmSci 360-AAPS Workshops of Drug Transporters in ADME: from the bench to the bedside, Mclean, VA, April 20-22, 2020 (Abstract accepted, did not present at this conference amid Covid-19).

Braydon Moore (Pharm. D. Candidate, Class of 2025), completed pharmacy pre-requisite course work at the University of Oklahoma in 2021. He is currently pursuing a Pharm. D. at the University of Oklahoma Health Sciences Center. He joined the Yue lab for special study in Spring 2023.


Khondoker Alam (PhD student 2012-2017), received MS degree in Clinical Pharmacy and Pharmacology from the University of Dhaka, Bangladesh. Khondoker joined US FDA in 2017 and is currently Pharmacology Reviewer at US FDA.

Awards and Internship training received during PhD:

  • E Blanche Sommers Scholarship Award ($2,500)-Outstanding Graduate Student in Pharmaceutical Sciences, OU College of Pharmacy, 2017

  • Harris Travel Award ($1,000), OU College of Pharmacy, 2015

  • Vertex Summer Internship, May-Aug, 2017, Vertex Pharmaceuticals, Boston

Publications and presentations from Yue Lab:

Publications:

  • Alam, K., Farasyn, T., Ding, K., Yue, W., Characterization of liver- and cancer-type-organic anion transporting polypeptide (OATP) 1B3 messenger RNA expression in normal and cancerous human tissues, Drug Metabolism Letters, 2018, 12:24-32, PMID: 29577869, PMCID: PMC6133766

  • Alam, K., Crowe, A., Wang, X. Zhang, X., Ding, K., Li, L., Yue, W., Regulation of organic anion transporting polypeptides (OATP) 1B1- and OATP1B3-mediated transport: an updated review in the context of OATP-mediated drug-drug interactions, International Journal of Molecular Sciences, 2018,19: 855, PMCID: PMC5877716

  • Alam, K., Farasyn, T., Crowe, A., Ding, K., and Yue, W. Treatment with Proteasome Inhibitor Bortezomib Decreases Organic Anion Transporting Polypeptide (OATP) 1B3-Mediated Transport in a Substrate-Dependent Manner, Public Library of Science ONE, 2017, 12:11 e0186924, PMID: 29107984, PMCID: PMC5673231

  • Pahwa, S., Alam, K., Crowe, A., Farasyn, T., Neuhoff, S., Hatley, O., Ding, K., and Yue W., Pretreatment With Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated Transport, Journal of Pharmaceutical Sciences, 2017, 106: 2123, PMID: 28373111, PMCID: 5511785

  • Alam, K., Pahwa, S., Wang, X., Zhang, P., Ding, K., Abuznait, A., Li L., and Yue W., Down-Regulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implications in OATP-Mediated Drug-Drug Interactions, Molecular Pharmaceutics, 2016, 13:839-51, PMID: 26750564, PMCID: PMC4970216

Presentations:

  • Alam, K., Wang, X., Zhang, P., Ding, K., Li, L., and Yue, W., Down-Regulation of OATP1B3 transport function by proteasome inhibitor bortezomib, American Association of Pharmaceutical Scientists (AAPS) Annual Meeting, Denver, CO, Nov. 2016

  • Alam, K., Crowe, A., Pahwa, S., and Yue, W., Altered Phosphorylation Status of OATP1B1 and 1B3 is Associated with Decreased Transport Function Following Cyclosporine A Treatment, Drug Metabolism Gordon Research Conference, Holderness, NH, July, 2016 (GRC Sponsored Presentation)

  • Alam, K., Alaa, A., Pahwa, S., Ding, K. and Yue, W., Indirect inhibition of organic anion transporting polypeptide (OATP) 1B1-mediated transport by lysosome inhibitor chloroquine, American Association of Pharmaceutical Scientists (AAPS)/International Transport Consortium (ITC) Joint Workshop on Drug Transporters, Baltimore, MD, April 20-22, 2015

  • Alam, K., Zhang, W., Fung, K., and Yue, W., Expression of liver- and cancer-type OATP1B3 in Cancer and non-malignant tissues. The Graduate Research Education and Technology Symposium (GREAT) of OUHSC, OKC, 2016, March 28-March 31, 2016

  • Alam, K., Zhang, W., Fung, K., and Yue, W., Expression of liver- and cancer-type OATP1B3 in Cancer and non-malignant tissues. The Stephenson Cancer Center Research Symposium OUHSC, Oklahoma City, Jan. 29, 2016

  • Alam, K., Alaa, A., Pahwa, S., Ding, K. and Yue, W., Indirect inhibition of organic anion transporting polypeptide (OATP) 1B1-mediated transport by lysosome inhibitor chloroquine, The Graduate Research Education and Technology Symposium (GREAT) of OUHSC, OKC, 2015, March 30-April 2, 2015

  • Alam, K., Powell, J., Ding, K. and Yue, W., Indirect inhibition of organic anion transporting polypeptide (OATP) 1B3-mediated transport by proteasome inhibitor bortezomib, The Stephenson Cancer Center Research Symposium OUHSC, Oklahoma City, Jan. 2015

  • Alam, K., Powell, J., Ding, K., and Yue, W., Inhibition of organic anion transporting polypeptide (OATP) 1B3-mediated drug transport by proteasome inhibitor bortezomib: implications in cancer therapy, The Stephenson Cancer Center Research Symposium OUHSC, Oklahoma City, Jan. 2015

  • Alam, K., Abuznait, A., and Yue, W., Down-regulation of organic anion transporting polypeptide (OATP) 1B3 function by proteasome inhibitor bortezomib, The Graduate Research Education and Technology Symposium (GREAT), OUHSC, 2014

  • Alam, K., Abuznait, A., Yue, W., Down-regulation of organic anion transporting polypeptide (OATP) 1B3 function by proteasome inhibitor bortezomib, The Stephenson Cancer Center Research Symposium OUHSC, Oklahoma City, Jan. 2014

Taleah Farasyn (PhD student 2013-2018), received BS degree in Biology/Chemistry from the University of Science and Arts of Oklahoma in 2012. She enrolled in the Graduate Program in Biomedical Sciences (GPiBS) at OUHSC in 2013 and joined the Yue lab in 2014. Currently, she is a Scientist at Quintara Discovery, Hayward, CA.

Awards and Internship training received during PhD:

      • 2015 AAPS Drug Transport Workshop Travel Award ($1,000)

      • 2018 Harris Travel Award ($1,000), OU College of Pharmacy

      • Clinical Pharmacology Summer Internship, May 22-Aug. 10, 2018 at Genentech, South San Francisco, CA

Publications and presentations from Yue Lab:

Publications:

  • Farasyn, T., Pahwa, S., Xu, C., and Yue, W., Pre-incubation with OATP1B1 and OATP1B3 inhibitors potentiates inhibitory effects in physiologically relevant sandwich-cultured primary human hepatocytes, European Journal of Pharmaceutical Sciences, 2021, 165: 105951, PMID: 34311070.

  • Farasyn, T., Xu, C., and Yue, W., Development of a primary rat sandwich-cultured hepatocytes model expressing functional human organic anion transporting polypeptide (OATP) 1B3: a novel tool to assess hepatobiliary disposition of human OATP1B3 substrates, Journal of Pharmacy and Pharmaceutical Sciences, 2021, 24: 475-483, PMID: 34516949

  • Kayesh, R., Farasyn, T., Crowe, A., Liu, Q., Pahwa, S., Alam, K., Neuhoff, S., Hatley, O., Ding, K. and Yue, W., Assessing OATP1B1- and OATP1B3-mediated drug-drug interaction potential of vemurafenib using R-value and physiologically based pharmacokinetic models, Journal of Pharmaceutical Sciences, 2021, 110: 314, PMID: 32590030, PMCID: PMC7750294

  • Farasyn, T., Crowe, A., Hatley, O., Neuhoff, S., Alam, K., Kanyod, J., Lam, T., Ding, K. and Yue, W., Preincubation with everolimus and sirolimus reduces organic anion transporting polypeptide (OATP)1B1- and 1B3-mediated transport independently of mTOR kinase inhibition: implication in assessing OATP1B1- and OATP1B3-mediated drug-drug interactions, J Pharm Sci., 2019, 108 (10): 3443-3456, PMID: 31047942, PMCID: PMC6759397

  • Alam, K., Farasyn, T., Ding, K., Yue, W., Characterization of liver- and cancer-type-organic anion transporting polypeptide (OATP) 1B3 messenger RNA expression in normal and cancerous human tissues, Drug Metabolism Letters, 2018, 12:24-32, PMID: 29577869, PMCID: PMC6133766

  • Alam, K., Farasyn, T., Crowe, A., Ding, K., and Yue, W. Treatment with Proteasome Inhibitor Bortezomib Decreases Organic Anion Transporting Polypeptide (OATP) 1B3-Mediated Transport in a Substrate-Dependent Manner, Public Library of Science ONE, 2017, 12:11 e0186924, PMID: 29107984, PMCID: PMC5673231

  • Pahwa, S., Alam, K., Crowe, A., Farasyn, T., Neuhoff, S., Hatley, O., Ding, K., and Yue W., Pretreatment With Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated Transport, Journal of Pharmaceutical Sciences, 2017, 106: 2123, PMID: 28373111, PMCID: 5511785

  • Powell, J., Farasyn, T., Kock, K., Meng, X., Pahwa, S., Brouwer, K.L.R., Yue, W., Novel mechanism of impaired function of organic anion transporting polypeptide (OATP) 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation, Drug Metabolism and Disposition, 2014, 42:1964-1970. PMID: 25200870, PMCID: PMC4201128

Presentations:

  • Farasyn, T., Alam, K., Crowe, A., Neuhoff, S., Hatley, O., Wang, X., Zhang, P., Ding, K., Li, L. and Yue, W., Assessing the OATP1B1- and OATP1B3-mediated drug-drug interaction potential of mammalian target of rapamycin (mTOR) inhibitor everolimus, Drug Metabolism and Pharmacokinetics, 2018, 33 (S1): S48 at 21st North American International Society for the Study of Xenobiotics (ISSX), Providence, RI, Sept., 2017

  • Farasyn, T., Alam, K., Crowe, A., Neuhoff, S., Hatley, O., Wang, X., Zhang, P., Ding, K., Li, L. and Yue, W., Down-Regulation of OATP1B1-Mediated Transport by Mammalian Target of Rapamycin (mTOR) Inhibitors Everolimus and Sirolimus: Potential Mechanism and Implication in OATP-Mediated Drug-Drug Interactions, The FASEB Journal, 2017, 31 (S1) at Experimental Biology Meeting, Chicago, IL, April, 2017

  • Farasyn, T., Powell, J., Ding, K., Yue, W., Rapid down-regulation of organic anion transporting polypeptide (OATP) 1B3 transport function by phosphorylation modulators in sandwich-cultured hepatocytes: a novel mechanism of OATP1B3 inhibition, Drug Metab Rev. 2015, 47(S1): 259, 19th North American ISSX and 29th JSSX Meeting San Francisco, CA, Oct. 19-23, 2014

  • Farasyn, T., Pahwa, S., Kayesh, R., Alam, K., Ding, K., Yue, W., Assessing OATP1B1- and OATP1B3-mediated drug-drug interaction potential of vemurafenib using static and physiologically based pharmacokinetic models, American Association of Pharmaceutical Scientists (AAPS)/International Transport Consortium (ITC) Joint Workshop on Drug Transporters in ADME: From the bench to the bedside, Dulles, VA, April 16-18, 2018 (Selected for Poster podium presentation among total of 6 being selected)

  • Farasyn, T., Alam, K., Crowe, A., Neuhoff, S., Hatley, O., Wang, X., Zhang, P., Ding, K., Li, L. and Yue, W., Multidisciplinary approach assessing OATP-mediated Drug Drug Interaction Potential of Everolimus, Drug Metabolism Gordon Research Conference, Holderness, NH, July, 2017

  • Farasyn, T., Wang, X., Zhang, P., Alam, K., Pahwa, S., Ding, K., Li, L., and Yue, W., Down-Regulation of OATP1B1 and 1B3 Transport Function by mTOR inhibitors Everolimus and Sirolimus: Potential Mechanism and Implications in OATP-Mediated Drug-Drug Interactions, , Drug Metabolism Gordon Research Conference, Holderness, NH, July, 2016

  • Farasyn, T., Pahwa, S., Ding, K., Alam, K., and Yue, W., Rapid Down-Regulation of Organic Anion Transporting Polypeptide (OATP) 1B1 and 1B3 Transport Function by Mammalian Target of Rapamycin (mTOR) Inhibitor Sirolimus, American Association of Pharmaceutical Scientists (AAPS)/International Transport Consortium (ITC) Joint Workshop on Drug Transporters, Baltimore, MD, April 20-22, 2015 (Travel Award, Oral and poster podium presentation)

  • Farasyn, T., Powell, J., Köck, K., Meng, X., Pahwa, S., Brouwer, K.L.R., and Yue, W., Post-translational regulation of organic anion transporting polypeptide (OATP)1B3 function by protein kinase C activation: a novel mechanism of hepatic OATP1B3 inhibition, Drug Metabolism Gordon Conference, Holderness, NH, July, 2014

  • Farasyn, T., Pahwa, S., Ding, K. and Yue, W., Rapid Down-Regulation of Organic Anion Transporting Polypeptide (OATP) 1B1 and 1B3 Transport Function by Mammalian Target of Rapamycin (mTOR) Inhibitor Sirolimus, The Graduate Research Education and Technology Symposium (GREAT) of OUHSC, OKC, 2015, March 30-April 2, 2015

Alexandra Crowe (PhD student 2014-2019), received B.S. degree from Emporia State University, Kansas. She enrolled in the GPiBS program in 2014, and joined the Yue lab in 2014. She is currently Associate Director, Clinical Pharmacology at Certara, Richmond Hill, GA.

Awards and Internship training received during PhD:

  • American Foundation of Pharmaceutical Education Predoctoral Award ($20,000), 2017-2019

  • John Bruce Scholarship Award ($5,000)-Outstanding Graduate Student in Pharmaceutical Sciences, OU College of Pharmacy, 2019

  • O. Ray Kling Award for Outstanding Graduate Student Leadership Award OUHSC ($1,000), Graduate College of OUHSC, 2019

  • Outstanding Senior Leadership Award OUHSC ($250), Graduate College of OUHSC, 2019

  • American Association of Pharmaceutical Scientist Best Abstract Award ($500): PharmSci 360-AAPS, 2018

  • American Association of Indian Pharmaceutical Scientist Graduate Award ($500), AAiPS, 2018

  • PharmSci 360-AAPS Travel Award ($1,000)

  • Institute of Quantitative Systems Pharmacology (IQSP) Internship, San Diego, CA, July-Dec. 2017

Publications and presentations from Yue Lab:

Publications:

  • Kayesh, R., Farasyn, T., Crowe, A., Liu, Q., Pahwa, S., Alam, K., Neuhoff, S., Hatley, O., Ding, K. and Yue, W., Assessing OATP1B1- and OATP1B3-mediated drug-drug interaction potential of vemurafenib using R-value and physiologically based pharmacokinetic models, Journal of Pharmaceutical Sciences, 2021, 110: 314, PMID: 32590030, PMCID: PMC7750294

  • Crowe, A., Yue, W., Semi-quantitative Determination of Protein Expression using Immunohistochemistry Staining and Analysis: An Integrated Protocol, Bio Protocol, 2019, 9 (24) e3465, PMID: 31867411, PMCID: PMC6924920

  • Crowe, A., Zheng, W., Miller, J., Pahwa, S., Alam, K., Fung, K., Rubin, E., Yin, F., Ding, K., Yue, W., Characterization of plasma membrane localization and phosphorylation status of organic anion transporting polypeptide (OATP) 1B1 c.521 T>C polymorphism, Pharm Res, 2019, 36: 101 (Cover image in 2019 July issue), PMID: 31093828

  • Alam, K., Crowe, A., Wang, X. Zhang, X., Ding, K., Li, L., Yue, W., Regulation of organic anion transporting polypeptides (OATP) 1B1- and OATP1B3-mediated transport: an updated review in the context of OATP-mediated drug-drug interactions, International Journal of Molecular Sciences, 2018,19: 855, PMCID: PMC5877716

  • Alam, K., Farasyn, T., Crowe, A., Ding, K., and Yue, W. Treatment with Proteasome Inhibitor Bortezomib Decreases Organic Anion Transporting Polypeptide (OATP) 1B3-Mediated Transport in a Substrate-Dependent Manner, Public Library of Science ONE, 2017, 12:11 e0186924, PMID: 29107984, PMCID: PMC5673231

  • Pahwa, S., Alam, K., Crowe, A., Farasyn, T., Neuhoff, S., Hatley, O., Ding, K., and Yue W., Pretreatment With Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated Transport, Journal of Pharmaceutical Sciences, 2017, 106: 2123, PMID: 28373111, PMCID: 5511785

Presentations:

  • Crowe, A., Zheng, W., Miller, J., Alam, K., Fung, K., Rubin, E., Yin, F., Ding, K., and Yue, W., Characterization of plasma membrane localization and phosphorylation status of organic anion transporting polypeptide (OATP) 1B1 c.521 T>C polymorphism, PharmSci 360-American Association of Pharmaceutical Scientists Annual Meeting, Washington DC, Nov. 4-7, 2018. [Crowe received AAPS travel ship and the Best Abstract Award]

  • Crowe, A., Alam, K., Pahwa, S., and Yue, W., Altered Phosphorylation Status of OATP1B1 and 1B3 is Associated with Decreased Transport Function Following Cyclosporine A Treatment, American Association of Pharmaceutical Scientists (AAPS) Annual Meeting, Denver, CO, Nov. 2016

Sonia Pahwa (Postdoctoral Fellow 2013-2016), Dr. Pahwa received her PhD degree from National Institute of Pharmaceutical Education and Research (NIPER), India in 2008. She then gained 3 years of industrial experience at Bristol Myers Squibb-Biocon R&D Center, India and 2-years of postdoctoral training at the Torrey Pines Institute of Molecular Studies in Florida. She joined the Yue lab in 2013, and joined US FDA in 2016.

Publications and presentations from Yue Lab:

Publications:

  • Pahwa, S., Alam, K., Crowe, A., Farasyn, T., Neuhoff, S., Hatley, O., Ding, K., and Yue W., Pretreatment With Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated Transport, Journal of Pharmaceutical Sciences, 2017, 106: 2123, PMID: 28373111, PMCID: 5511785

  • Farasyn, T., Pahwa, S., Xu, C., and Yue, W., Pre-incubation with OATP1B1 and OATP1B3 inhibitors potentiates inhibitory effects in physiologically relevant sandwich-cultured primary human hepatocytes, European Journal of Pharmaceutical Sciences, 2021, 165: 105951, PMID: 34311070.

  • Alam, K., Pahwa, S., Wang, X., Zhang, P., Ding, K., Abuznait, A. ‡, Li L., and Yue W., Down-Regulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implications in OATP-Mediated Drug-Drug Interactions, Molecular Pharmaceutics, 2016, 13:839-51, PMID: 26750564, PMCID: PMC4970216

  • Kayesh, R., Farasyn, T., Crowe, A., Liu, Q., Pahwa, S., Alam, K., Neuhoff, S., Hatley, O., Ding, K. and Yue, W., Assessing OATP1B1- and OATP1B3-mediated drug-drug interaction potential of vemurafenib using R-value and physiologically based pharmacokinetic models, Journal of Pharmaceutical Sciences, 2021, 110: 314, PMID: 32590030, PMCID: PMC7750294

  • Crowe, A., Zheng, W., Miller, J., Pahwa, S., Alam, K., Fung, K., Rubin, E., Yin, F. ‡, Ding, K., Yue, W., Characterization of plasma membrane localization and phosphorylation status of organic anion transporting polypeptide (OATP) 1B1 c.521 T>C polymorphism, Pharm Res, 2019, 36: 101 (Cover image in 2019 July issue), PMID: 31093828

  • Powell, J., Farasyn, T., Kock, K., Meng, X., Pahwa, S., Brouwer, K.L.R., Yue, W., Novel mechanism of impaired function of organic anion transporting polypeptide (OATP) 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation, Drug Metabolism and Disposition, 2014, 42:1964-1970. PMID: 25200870, PMCID: PMC4201128

Presentations:

  • Pahwa, S., Farasyn, T., Alam, K., Crowe, A., Ding, K., and Yue, W., Pretreatment with Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated Transport, American Association of Pharmaceutical Scientists (AAPS) Annual Meeting, Denver, CO, Nov. 2016

  • Pahwa, S., Alam, K., Woo, S. and Yue, W., Pre-Incubation Potentiates the Inhibitory Effects of Tyrosine Kinase Inhibitors toward OATP1B1- and 1B3-Mediated Transport, American Association of Pharmaceutical Scientists (AAPS)/International Transport Consortium (ITC) Joint Workshop on Drug Transporters, Baltimore, MD, April 20-22, 2015

  • Pahwa, S. and Yue, W., Can cancer patients safely take kinase inhibitor drugs and statins together? Prediction of OATP-mediated drug-drug interactions of TKIs against rosuvastatin, Drug Metabolism Gordon Conference, Holderness, NH, July, 2014 (GRC Sponsored Presentation)

  • Pahwa, S. and Yue, W., Can cancer patients safely take kinase inhibitor drugs and statins together? The Graduate Research Education and Technology Symposium (GREAT) of OUHSC, 2014 (Oral presentation competition)

  • Pahwa, S., Powell, J., and Yue, W. Regulation of organic anion transporting polypeptides by tyrosine kinase inhibitors, The Stephenson Cancer Center Research Symposium OUHSC, Oklahoma City, Jan. 2014

Alaa Abuznait (Postdoctoral Fellow 2013-2014), Dr. Abuznait joined the Yue lab in 2013 after receiving his PhD degree in Pharmaceutics and Pharmacokinetics from University of Louisiana at Monroe, Monroe, LA. He joined US FDA as pharmacologist/bioequivalence reviewer in 2014.

Publications and presentations from Yue Lab:

Publication:

  • Alam, K., Pahwa, S., Wang, X., Zhang, P., Ding, K., Abuznait, A., Li L., and Yue W., Down-Regulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implications in OATP-Mediated Drug-Drug Interactions, Molecular Pharmaceutics, 2016, 13:839-51, PMID: 26750564, PMCID: PMC4970216

Presentation:

  • Abuznait, A., Powell, J., Girton M., Yue, W., Regulation of OATP1B1 degradation and trafficking via ubiquitin-proteasome pathway, The Stephenson Cancer Center Research Symposium OUHSC, Oklahoma City, Jan. 2014

Xiaojie Meng (Postdoctoral Fellow 2012-2013), Dr. Meng received her PhD degree from Kagoshima University, Japan in 2009.

Publications and presentations from Yue Lab:

Publication:

  • Powell, J., Farasyn, T., Kock, K., Meng, X., Pahwa, S., Brouwer, K.L.R., Yue, W., Novel mechanism of impaired function of organic anion transporting polypeptide (OATP) 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation, Drug Metabolism and Disposition, 2014, 42:1964-1970. PMID: 25200870, PMCID: PMC4201128

Presentation:

John Powell (Research Technician, 2013-2014), received his BS degree in Biology from Oral Roberts University, Tulsa, OK in 2013. In 2014, he entered the PhD program of Yale University, Graduate School of Arts and Sciences, New Haven, CT.

Publications and presentations from Yue Lab:

Publication:

  • Powell, J., Farasyn, T., Kock, K., Meng, X., Pahwa, S., Brouwer, K.L.R., Yue, W., Novel mechanism of impaired function of organic anion transporting polypeptide (OATP) 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation, Drug Metabolism and Disposition, 2014, 42:1964-1970. PMID: 25200870, PMCID: PMC4201128

Jonathan Miller (Research Technician, 2017-2018), joined the Yue lab in 2017 after receiving his B.S. degree in Molecular and Cell Biology from Oklahoma Christian University. Jonathan entered OU Medical School in 2018, and is now a resident at OU Medical Center.


Publications from Yue Lab:

Publications:

  • Crowe, A., Miller, J., Yue, W., Genotyping of the OATP1B1 c. 521 T>C polymorphism from the Formalin-Fixed Paraffin-Embedded (FFPE) tissue specimens: an optimized protocol, Bio-Protocol, 2019, 9(16): e3343. PMID: 31840034, PMCID: PMC6909936

  • Crowe, A. , Zheng, W., Miller, J. , Pahwa, S. , Alam, K. , Fung, K., Rubin, E., Yin, F. ‡, Ding, K., Yue, W., Characterization of plasma membrane localization and phosphorylation status of organic anion transporting polypeptide (OATP) 1B1 c.521 T>C polymorphism, Pharm Res, 2019, 36: 101 (Cover image in 2019 July issue), PMID: 31093828

Mary Girton (Research Technician, 2012-2013), received her BS degree in Biology from Kennesaw State University, Kennesaw, GA in 2012. Mary pursued Doctor of Veterinary Medicine degree at Oklahoma State University in 2013