Postdoctoral position to use genetics to aid in genetic and chemical validation of cell wall targets in fungal pathogens

Job Title:                               Postdoctoral Research Assistant

School:                                  Life Sciences

Unit:                                       Gene Regulation and Expression

Grade:                                   Grade 7 (£31,076 - £38,183)

Job Category:                     Research

Closing Date:                      12 February 2017

Postdoctoral position to use genetics to aid in genetic and chemical validation of cell wall targets in fungal pathogens in the laboratory of Professor Daan van Aalten FRSE.

A postdoc position is available immediately in the group of Daan van Aalten at the School of Life Sciences in Dundee, Scotland. Funded by a recently awarded 1.9M GBP MRC Programme Grant, you will use genetics to investigate the contribution of a range of carbohydrate-active enzymes to the biogenesis of the fungal cell wall, and study the effects of specific inhibitors on fungal pathogens.

You will be working in a highly international research group that operates across the disciplines of cell biology, enzymology, drug design, structural biology and synthetic chemistry to discover the molecular mechanisms of fungal cell wall assembly and exploit these for the development of novel antifungal targets. More information on the group can be found on
http://www.lifesci.dundee.ac.uk/people/daan_van_aalten. Training, as required, will be provided in a well-equipped, well-funded and supportive environment enabling the successful candidate to extend skills and expertise. The School has excellent facilities for all aspects of research, including in-house and easily accessible services, such as cloning, proteomics, microscopy, DNA sequencing, oligo synthesis and preparation of growth media.

You will use state of the art CRISPR/Cas9 for genome editing to generate catalytically inactive versions of a collection of cell wall genes. This position is available for 24 months in the first instance, with possible extension for another 3 years. Starting date is in spring 2017.

Candidate requirements:

Essential:

- A background in genetics on fungal pathogens
- PhD with an outstanding track record and at least one first authored publication in an internationally recognised peer-reviewed journal
- Capable of working in a team, but able to generate ideas, plan and work independently
- A desire to interact with, and learn from, scientists beyond your own discipline/culture
- Excellent communication skills and proficiency in English, in particular in writing scientific publications

Desirable:

- A background in biochemistry, molecular biology, signal transduction and or pharmacology would be preferable
- Familiarity with protein glycosylation and related disorders
- Experience with CRISPR/Cas9

For informal enquiries please contact Daan van Aalten (dmfvanaalten@dundee.ac.uk). For details on the van Aalten lab please visit our website
http://www.lifesci.dundee.ac.uk/people/daan-van-aalten. The van Aalten lab is based in the Centre for Gene Regulation and Expression and is an exciting and collaborative research environment, equipped to the highest international standards. The School of Life Sciences is in a beautiful location overlooking the estuary of the River Tay. This is one of the premier Life Sciences research centres in the world and was recently assessed as the top UK University for Life Sciences research in the 2014 Research Excellence Framework (REF).

How to apply:

To apply on-line please visit:
www.dundee.ac.uk/jobs

The University of Dundee is a diverse community and is committed to equality of opportunity for all by providing a supportive, flexible and inclusive working environment.  We have family friendly policies (including flexible working and childcare vouchers), staff groups for LGBT and BME; and prayer room facilities.

The University of Dundee has received the Athena SWAN Bronze Award (
http://www.dundee.ac.uk/about/athenaswan/) which recognises the promotion of gender equality and has made further commitment to advancing inclusive culture which supports and encourages all under-represented groups.

The University of Dundee is a Scottish Registered Charity, No. SC015096.

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