26.10.11-vergelijking ME-criteria leidt tot nieuwe criteria(Jason & al.)

Jason en kollega's van de DePaul University hebben de verschillende ME-kriteria met elkaar vergeleken en geanalyseerd wat de overeenkomsten zijn.
 Op basis van die overeenkomsten komen zij tot nieuwe konsensuskriteria voor ME:
Majeure Symptomen die altijd aanwezig zijn:     
    1.post-exertional malaise,
    2.neurologische abnormaliteiten (geheugen- en koncentratieproblemen etc.) en 
    3.autonome dysfunctie (orthostatische intolerantie etc.)

Secundaire symptomen zijn :     

  1. pijn,
  2. endocriene afwijkingen,
  3. immunologische symptomen (koortsgevoel, gezwollen lymfeklieren etc.)
  4. slaapstoornissen.
De ME-consensus-kriteria van Jason en zijn kollega's zijn, zo blijkt uit hun analyse, strenger dan die van de onlangs gepubliceerde internationale consensus-kriteria.


Het goede nieuws is dat deze studie, net zoals de ICC een duidelijk onderscheid maakt tussen ME (het hoofdkenmerk: post-exertional malaise) en CVS (hoofdkenmerk: "vermoeidheid").

Maar... we worden nog maar eens geconfronteerd met nieuwe criteria... terwijl "de nieuwe Internationale Consensus Criteria" nog maar recent zijn bekend gemaakt.... en zelfs door velen nog niet gekend zijn.




In summary,

the current review of ME case definitions focuses on the major features of the illness, and suggests that ME has an acute onset that can be categorized into three categories:

ME-viral, in which ME is precipitated by a virus;

ME-infectious non-viral, in which ME is precipitated by a non-viral infection such as a tick bite resulting in Lyme disease; and

ME-other, in which ME is precipitated by trauma or chemical exposure.


The major symptom categories of ME include:

post-exertional malaise, and

neurological and

autonomic manifestations.


Postexertional malaise can be described as prolonged restoration of muscle power following either mental or physical exertion with recovery often taking 2–24 hours or longer.

Neurological manifestations, which include short-term memory loss, loss of powers of concentration, cognitive dysfunction, increased irritability, confusion, perceptual difficulties, as well as evidence of central nervous system and/or brain injury.

Autonomic dysfunction, which can incorporate neutrally mediated hypotension, postural orthostatic tachycardia, delayed postural hypotension, palpitations with or without cardiac  arrhythmias, dizziness, feeling unsteady on one’s feet, disturbed balance, cold extremities, hypersensitivity to climate change, cardiac irregularity, Raynaud’s phenomenon, circulating blood volume decrease, and shortness of breath.  

Secondary features of ME include


endocrine manifestations,

immune manifestations, and

sleep dysfunction.




Myalgic Encephalomyelitis Case Definitions

Automatic Control of Physiological State and Function. 2012; 1.


Leonard A. Jason, Dylan Damrongvachiraphan, Jessica Hunnell, Lindsey Bartgis, Abigail Brown, Meredyth Evans, and Molly Brown




This article reviews a Myalgic Encephalomyelitis (ME) case definition based on criteria offered over the past five decades.

The current paper looks to review case definitions for ME based on

In general, these theorists have argued that ME is now defined differently than chronic fatigue syndrome because ME involves an acute onset, post-exertional malaise and neurocognitive problems, and fatigue is not a major criteria.

We will compare these theorists to the recently published International Consensus Criteria for Myalgic Encephalomyelitis.

We will also attempt to consolidate aspects of different current definitions in order to suggest possible core features of ME.

This article will also recommend the importance of providing explicit, objective criteria on specific key symptoms.

In addition, structured interview schedules along with specific medical tests are recommended to assure this illness is assessed in a consistent way across settings.
It is hoped these developments will lead to increased reliability of the ME case definition, as well as more frequent use of these criteria by investigators.


http://condor.depaul.edu/ljason/cfs/publications.html: List of publications on ME and CFS by Leonard Jason's DePaul Research Group