Human Embryonic Stem Cell and Induced Pluripotent Stem Cells
Bioinspired Systems for Regenerative Medicine
Our lab engineers three-dimensional, polymer-based scaffolds to mimic the natural extracellular matrix by providing biological, chemical, and mechanical cues to cells. These scaffolds are designed for tissue repair in various organ systems. Scaffold systems used include hydrogels, electrospun fibers, and interpenetrating polymer networks.
Our lab modifies surface chemistry using various techniques, such as grafted polymer networks and oxygen plasma treatment, to create platforms for studying cell/interface and cell/cell interactions. These surfaces are used for cellular patterning, cell shape control, ligand conjugation and presentation, and cell adhesion and mechanotransduction studies.
Willie Mae Reese
Microphysiology Systems for Drug Toxicity Screening in Heart and Liver Tissues*
Drug discovery and development is hampered by high failure rates attributed to the reliance on non-human animal models employed during safety and efficacy testing. Here, we try to establish in vitro models of human cardiac and liver tissue. We propose to use a combination of integrated microfluidic systems with electrical and optical detection capability, dynamic controls, and advanced biomaterials to regulate structural organization function of cardiomyocytes and hepatocytes.
* In collaboration with Prof. Luke Lee