Projects

Human Embryonic Stem Cell and Induced Pluripotent Stem Cells
Current research in our lab on human embryonic stem cells is focused on developing artificial and well-defined cell culture protocols.  Elimination of animal products in cell culture is a critical step in the maintenance and directed differentiation of potential therapeutic cell lines.   

Researchers:

   Natalie Marks
   Micaela Finnegan
   Zhen Ma
   Kaifeng Shao
   Anusuya Ramasubramanium






Bioinspired Systems for Regenerative Medicine
Our lab engineers three-dimensional, polymer-based scaffolds to mimic the natural extracellular matrix by providing biological, chemical, and mechanical cues to cells.  These scaffolds are designed for tissue repair in various organ systems.  Scaffold systems used include hydrogels, electrospun fibers, and interpenetrating polymer networks.

Researchers:

   Amit Jha
   Nik Rode
   Wes Jackson
   Cara Brown
   Mariana Garcia
   Felicia Svedlund   
   Eda Altiok
   Sylvia Natividad-Diaz



Biological Interfaces
Our lab modifies surface chemistry using various techniques, such as grafted polymer networks and oxygen plasma treatment, to create platforms for studying cell/interface and cell/cell interactions.  These surfaces are used for cellular patterning, cell shape control, ligand conjugation and presentation, and cell adhesion and mechanotransduction studies.

Researchers:

   Anurag Mathur
   Peter Loskill 
   Jason Wang
   Willie Mae Reese



Microphysiology Systems for Drug Toxicity Screening in Heart and Liver Tissues*
Drug discovery and development is hampered by high failure rates attributed to the reliance on non-human animal models employed during safety and efficacy testing.  Here, we try to establish in vitro models of human cardiac and liver tissue.  We propose to use a combination of integratemicrofluidic systems with electrical and optical detection capability, dynamic controls, and advanced biomaterials to regulate structural organization function of cardiomyocytes and hepatocytes.

* In collaboration with Prof. Luke Lee

Researchers:

  Natalie Marks
  Micaela Finnegan
  Anurag Mathur  
  Peter Loskill
  Zhen Ma
  Kaifeng Shao
 

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