Research

Research in the Shah lab converges at the intersections of gastrointestinal homeostasis, inflammation, and cancer. Our body must respond to the metabolic demands of a low oxygen (hypoxic) environment. Chronic hypoxia can lead to inflammation and can ultimately progress toward a cancer phenotype. Our lab investigates the molecular mechanisms that regulate hypoxia which will help improve existing cancer therapy.

My current projects investigate the role of Itaconate (a metabolite of the TCA cycle) which is involved in cellular metabolism as an anti-inflammatory signaling molecule. A separate more long term project explores the impact of enrichment on anxiety-like behavior in mice and the impact of enrichment on gut microbiota. Understanding how enrichment impacts the brain and behavior directs continued investigation of the gut-brain-microbiome axis and tumor suppression in mice and humans. 
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